(2R,11aS)-2-hydroxy-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione

Base Information

Chemical Name:(2R,11aS)-2-hydroxy-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione
CAS No.:50424-51-6
Molecular Formula:C₁₂H₁₂N₂O₃
Molecular Weight:232.239
Hs Code.:

Synonyms:(2R,11aS)-2-hydroxy-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione

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Chemical Property of (2R,11aS)-2-hydroxy-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione

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Technology Process of (2R,11aS)-2-hydroxy-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione

There total 27 articles about (2R,11aS)-2-hydroxy-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 313644-37-0
N-(2-azidobenzoyl)-L-4-trans-hydroxyproline methyl ester

: 50424-51-6,182823-26-3
(2R,11aS)-2-hydroxy-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione

Guidance literature:: With boron trifluoride diethyl etherate; sodium iodide; In acetonitrile; at 20 ℃; for 1.13333h;
DOI:10.1055/s-2008-1072742

Reference yield: 90.0%

: 118-48-9
isatoic anhydride

: 51-35-4,30724-02-8
4R-4-hydroxyproline

: 50424-51-6,182823-26-3
(2R,11aS)-2-hydroxy-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione

Guidance literature:: DOI:10.3987/com-03-9810

Reference yield: 90.0%

: 50424-51-6,182823-26-3
(2R,11aS)-2-hydroxy-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione

Guidance literature:: resin-bound (2S,4R)-1-(2-azidobenzoyl)-4-hydroxy-pyrrolidine-2-carboxylic acid methyl ester; With aluminium; nickel dichloride; In tetrahydrofuran; at 20 ℃; for 0.5h;

With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 2h;
DOI:10.1016/S0040-4039(03)01049-9