(1,1-Dimethyl-2-{(R)-2-oxo-1-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylcarbamoyl}-ethyl)-sulfamic acid methyl ester

Base Information

• Chemical Name: (1,1-Dimethyl-2-{(R)-2-oxo-1-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylcarbamoyl}-ethyl)-sulfamic acid methyl ester
• CAS No.: 174222-36-7
• Molecular Formula: C₄₉H₄₇N₇O₅S
• Molecular Weight: 846.022
• Mol file: 174222-36-7.mol

Synonyms:(1,1-Dimethyl-2-{(R)-2-oxo-1-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylcarbamoyl}-ethyl)-sulfamic acid methyl ester

Chemical Property of (1,1-Dimethyl-2-{(R)-2-oxo-1-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylcarbamoyl}-ethyl)-sulfamic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1,1-Dimethyl-2-{(R)-2-oxo-1-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylcarbamoyl}-ethyl)-sulfamic acid methyl ester

There total 3 articles about (1,1-Dimethyl-2-{(R)-2-oxo-1-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylcarbamoyl}-ethyl)-sulfamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole (133051-88-4) + [1,1-Dimethyl-2-((R)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylcarbamoyl)-ethyl]-sulfamic acid methyl ester (145486-46-0) → (1,1-Dimethyl-2-{(R)-2-oxo-1-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylcarbamoyl}-ethyl)-sulfamic acid methyl ester (174222-36-7)

Guidance literature:

With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃;

DOI:10.1016/0040-4039(95)02033-0

Reference yield:

2,2-dimethyl-4-oxo-azetidine-1-sulfonyl chloride (17174-96-8) → (1,1-Dimethyl-2-{(R)-2-oxo-1-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylcarbamoyl}-ethyl)-sulfamic acid methyl ester (174222-36-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / triethylamine / 0 °C / to room temperature

2: 89 percent / sodium hydride / tetrahydrofuran; dimethylformamide / 0 °C

With sodium hydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/0040-4039(95)02033-0

Reference yield:

(R)-3-amino-2,3,4,5-tetrahydro-1H-[1]-benzazepin-2-one (137036-55-6) → (1,1-Dimethyl-2-{(R)-2-oxo-1-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylcarbamoyl}-ethyl)-sulfamic acid methyl ester (174222-36-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / triethylamine / 0 °C / to room temperature

2: 89 percent / sodium hydride / tetrahydrofuran; dimethylformamide / 0 °C

With sodium hydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/0040-4039(95)02033-0

upstream raw materials:

N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

[1,1-Dimethyl-2-((R)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylcarbamoyl)-ethyl]-sulfamic acid methyl ester

2,2-dimethyl-4-oxo-azetidine-1-sulfonyl chloride

(R)-3-amino-2,3,4,5-tetrahydro-1H-[1]-benzazepin-2-one