5-(2-chloro-pyridin-4-yl)-5-(3-cyclopropyl-4-difluoromethoxy-5-methyl-phenyl)-5H-pyrrolo[3,4-b]pyridin-7-ylamine

Base Information

Chemical Name:5-(2-chloro-pyridin-4-yl)-5-(3-cyclopropyl-4-difluoromethoxy-5-methyl-phenyl)-5H-pyrrolo[3,4-b]pyridin-7-ylamine
CAS No.:1226800-02-7
Molecular Formula:C₂₃H₁₉ClF₂N₄O
Molecular Weight:440.88
Hs Code.:

Synonyms:5-(2-chloro-pyridin-4-yl)-5-(3-cyclopropyl-4-difluoromethoxy-5-methyl-phenyl)-5H-pyrrolo[3,4-b]pyridin-7-ylamine

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Chemical Property of 5-(2-chloro-pyridin-4-yl)-5-(3-cyclopropyl-4-difluoromethoxy-5-methyl-phenyl)-5H-pyrrolo[3,4-b]pyridin-7-ylamine

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Technology Process of 5-(2-chloro-pyridin-4-yl)-5-(3-cyclopropyl-4-difluoromethoxy-5-methyl-phenyl)-5H-pyrrolo[3,4-b]pyridin-7-ylamine

There total 1 articles about 5-(2-chloro-pyridin-4-yl)-5-(3-cyclopropyl-4-difluoromethoxy-5-methyl-phenyl)-5H-pyrrolo[3,4-b]pyridin-7-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1226800-01-6
5-bromo-1-cyclopropyl-2-difluoromethoxy-3-methyl-benzene

: 1226799-98-9
2-methyl-propane-2-sulfinic acid (2-chloro-pyridin-4-yl)-(2-cyano-pyridin-3-yl)-methyleneamide

: 1226800-02-7
5-(2-chloro-pyridin-4-yl)-5-(3-cyclopropyl-4-difluoromethoxy-5-methyl-phenyl)-5H-pyrrolo[3,4-b]pyridin-7-ylamine

Guidance literature:: 5-bromo-1-cyclopropyl-2-difluoromethoxy-3-methyl-benzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃;

2-methyl-propane-2-sulfinic acid (2-chloro-pyridin-4-yl)-(2-cyano-pyridin-3-yl)-methyleneamide; In tetrahydrofuran; hexane; at -78 ℃;

Reference yield: 45.0%

: 1226800-02-7
5-(2-chloro-pyridin-4-yl)-5-(3-cyclopropyl-4-difluoromethoxy-5-methyl-phenyl)-5H-pyrrolo[3,4-b]pyridin-7-ylamine

: 109299-78-7
pyrimidine 5-boronic acid

: 1226799-57-0
5-(3-cyclopropyl-4-difluoromethoxy-5-methyl-phenyl)-5-(2-pyrimidin-5-yl-pyridin-4-yl)-5H-pyrrolo[3,4-b]pyridin-7-ylamine

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; at 90 ℃; for 16h; Inert atmosphere; Sealed tube;