(2S,6S,7S,10R)-7-isopropyl-10-methyl-2-<(4-methylbenzenesulfonyl)oxy>-1,5-dioxaspiro<5,5>undecane

Base Information

Chemical Name:(2S,6S,7S,10R)-7-isopropyl-10-methyl-2-<(4-methylbenzenesulfonyl)oxy>-1,5-dioxaspiro<5,5>undecane
CAS No.:138603-01-7
Molecular Formula:C₂₂H₃₄O₅S
Molecular Weight:410.575
Hs Code.:

Synonyms:(2S,6S,7S,10R)-7-isopropyl-10-methyl-2-<(4-methylbenzenesulfonyl)oxy>-1,5-dioxaspiro<5,5>undecane

Suppliers and Price of (2S,6S,7S,10R)-7-isopropyl-10-methyl-2-<(4-methylbenzenesulfonyl)oxy>-1,5-dioxaspiro<5,5>undecane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,6S,7S,10R)-7-isopropyl-10-methyl-2-<(4-methylbenzenesulfonyl)oxy>-1,5-dioxaspiro<5,5>undecane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,6S,7S,10R)-7-isopropyl-10-methyl-2-<(4-methylbenzenesulfonyl)oxy>-1,5-dioxaspiro<5,5>undecane

There total 13 articles about (2S,6S,7S,10R)-7-isopropyl-10-methyl-2-<(4-methylbenzenesulfonyl)oxy>-1,5-dioxaspiro<5,5>undecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 135067-28-6,135211-98-2
2-((6R,7S,10R)-7-Isopropyl-10-methyl-1,5-dioxa-spiro[5.5]undec-2-yl)-ethanol

: 98-59-9
p-toluenesulfonyl chloride

: 138603-01-7
(2S,6S,7S,10R)-7-isopropyl-10-methyl-2-<(4-methylbenzenesulfonyl)oxy>-1,5-dioxaspiro<5,5>undecane

: 138490-41-2
(2R,6S,7S,10R)-7-isopropyl-10-methyl-2-<(4-methylbenzenesulfonyl)oxy>-1,5-dioxaspiro<5,5>undecane

Guidance literature:: With pyridine; at 25 ℃; for 4h;
DOI:10.1021/jo00031a019

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 2-((6S,7S,10R)-7-isopropyl-10-methyl-1,5-dioxaspiro[5.5]undecan-2-yl)ethanol

: 2-((2R,6S,7S,10R)-7-isopropyl-10-methyl-1,5-dioxaspiro-[5.5]-undecan-2-yl)ethyl 4-methylbenzenesulfonate

: 138603-01-7
(2S,6S,7S,10R)-7-isopropyl-10-methyl-2-<(4-methylbenzenesulfonyl)oxy>-1,5-dioxaspiro<5,5>undecane

Guidance literature:: With dmap; In dichloromethane; at 0 - 20 ℃; for 3h; Overall yield = 60 %; Overall yield = 5.89 g;
DOI:10.1016/j.bmcl.2015.06.060

Reference yield:

: 4328-94-3
pentane-1,3,5-triol

: 138603-01-7
(2S,6S,7S,10R)-7-isopropyl-10-methyl-2-<(4-methylbenzenesulfonyl)oxy>-1,5-dioxaspiro<5,5>undecane

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) TsOH, HC(OMe)3, 2.) 1N NaOH / 1.) CH₂Cl₂, room temperature, overnight, 2.) MeOH, room temperature, 12 h.

2: DMAP / CH₂Cl₂

With dmap; sodium hydroxide; toluene-4-sulfonic acid; trimethyl orthoformate; In dichloromethane;
DOI:10.1021/jo962217a