methyl 1-phenyl-2-{[2-phenyl-3-(piperazin-1-ylmethyl)quinolin-4-yl]carbonyl}hydrazinecarboxylate

Base Information

Chemical Name:methyl 1-phenyl-2-{[2-phenyl-3-(piperazin-1-ylmethyl)quinolin-4-yl]carbonyl}hydrazinecarboxylate
CAS No.:914653-28-4
Molecular Formula:C₂₉H₂₉N₅O₃
Molecular Weight:495.581
Hs Code.:

Synonyms:methyl 1-phenyl-2-{[2-phenyl-3-(piperazin-1-ylmethyl)quinolin-4-yl]carbonyl}hydrazinecarboxylate

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Chemical Property of methyl 1-phenyl-2-{[2-phenyl-3-(piperazin-1-ylmethyl)quinolin-4-yl]carbonyl}hydrazinecarboxylate

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Technology Process of methyl 1-phenyl-2-{[2-phenyl-3-(piperazin-1-ylmethyl)quinolin-4-yl]carbonyl}hydrazinecarboxylate

There total 5 articles about methyl 1-phenyl-2-{[2-phenyl-3-(piperazin-1-ylmethyl)quinolin-4-yl]carbonyl}hydrazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 914653-27-3
tert-butyl 4-[(4-{[2-(methoxycarbonyl)-2-phenylhydrazino]carbonyl}-2-phenylquinolin-3-yl)methyl]piperazine-1-carboxylate

: 914653-28-4
methyl 1-phenyl-2-{[2-phenyl-3-(piperazin-1-ylmethyl)quinolin-4-yl]carbonyl}hydrazinecarboxylate

Guidance literature:: tert-butyl 4-[(4-{[2-(methoxycarbonyl)-2-phenylhydrazino]carbonyl}-2-phenylquinolin-3-yl)methyl]piperazine-1-carboxylate; With trifluoroacetic acid; for 1h;

With water; potassium carbonate; In ethyl acetate;

Reference yield:

: 875755-01-4
3-methyl-2-phenyl-4-quinolinecarboxylic acid, 2-(methoxycarbonyl)-2-phenylhydrazide

: 914653-28-4
methyl 1-phenyl-2-{[2-phenyl-3-(piperazin-1-ylmethyl)quinolin-4-yl]carbonyl}hydrazinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: NaH / tetrahydrofuran

2: NBS / CCl₄ / Irradiation

3: TFA / CH₂Cl₂

4: Et₃N / tetrahydrofuran / Heating

With N-Bromosuccinimide; sodium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; tetrachloromethane; dichloromethane;
DOI:10.1016/j.bmcl.2006.08.085

Reference yield:

: 1-tert-butyl 2-methyl 1-(3-methyl-2-phenylquinoline-4-carbonyl)-2-phenylhydrazine-1,2-dicarboxylate

: 914653-28-4
methyl 1-phenyl-2-{[2-phenyl-3-(piperazin-1-ylmethyl)quinolin-4-yl]carbonyl}hydrazinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: NBS / CCl₄ / Irradiation

2: TFA / CH₂Cl₂

3: Et₃N / tetrahydrofuran / Heating

With N-Bromosuccinimide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; tetrachloromethane; dichloromethane;
DOI:10.1016/j.bmcl.2006.08.085