N-(Benzyloxycarbonyl)-3-<1,2-didehydro-2-(ethoxycarbonyl)ethyl>-2,2-di(<2H3>methyl)-4,4-dimethylpyrrolidine

Base Information

Chemical Name:N-(Benzyloxycarbonyl)-3-<1,2-didehydro-2-(ethoxycarbonyl)ethyl>-2,2-di(<2H3>methyl)-4,4-dimethylpyrrolidine
CAS No.:139461-56-6
Molecular Formula:C₂₁H₂₉NO₄
Molecular Weight:365.418
Hs Code.:

Synonyms:N-(Benzyloxycarbonyl)-3-<1,2-didehydro-2-(ethoxycarbonyl)ethyl>-2,2-di(<2H3>methyl)-4,4-dimethylpyrrolidine

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Chemical Property of N-(Benzyloxycarbonyl)-3-<1,2-didehydro-2-(ethoxycarbonyl)ethyl>-2,2-di(<2H3>methyl)-4,4-dimethylpyrrolidine

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Technology Process of N-(Benzyloxycarbonyl)-3-<1,2-didehydro-2-(ethoxycarbonyl)ethyl>-2,2-di(<2H3>methyl)-4,4-dimethylpyrrolidine

There total 5 articles about N-(Benzyloxycarbonyl)-3-<1,2-didehydro-2-(ethoxycarbonyl)ethyl>-2,2-di(<2H3>methyl)-4,4-dimethylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 139493-27-9
N-(Benzyloxycarbonyl)-3-formyl-2,2-di(<2H3>methyl)-4,4-dimethylpyrrolidine

: 1099-45-2
ethyl (triphenylphosphoranylidene)acetate

: 139461-56-6
N-(Benzyloxycarbonyl)-3-<1,2-didehydro-2-(ethoxycarbonyl)ethyl>-2,2-di(<2H3>methyl)-4,4-dimethylpyrrolidine

Guidance literature:: In benzene; at 60 ℃; for 1h;
DOI:10.1021/jo00034a020

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 139461-56-6
N-(Benzyloxycarbonyl)-3-<1,2-didehydro-2-(ethoxycarbonyl)ethyl>-2,2-di(<2H3>methyl)-4,4-dimethylpyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / K₂CO₃ / acetonitrile / 2.5 h / -20 °C

2: 91 percent / pyridinium chlorochromate / CH₂Cl₂ / 3 h / 25 °C

3: 85 percent / benzene / 1 h / 60 °C

With potassium carbonate; pyridinium chlorochromate; In dichloromethane; acetonitrile; benzene;
DOI:10.1021/jo00034a020

Reference yield:

: 139461-54-4
2,2-Di(<2H3>methyl)-4,4-dimethyl-3-(hydroxymethyl)-1-pyrrolidine

: 139461-56-6
N-(Benzyloxycarbonyl)-3-<1,2-didehydro-2-(ethoxycarbonyl)ethyl>-2,2-di(<2H3>methyl)-4,4-dimethylpyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / K₂CO₃ / acetonitrile / 2.5 h / -20 °C

2: 91 percent / pyridinium chlorochromate / CH₂Cl₂ / 3 h / 25 °C

3: 85 percent / benzene / 1 h / 60 °C

With potassium carbonate; pyridinium chlorochromate; In dichloromethane; acetonitrile; benzene;
DOI:10.1021/jo00034a020