3-[4-(4-Methanesulfonylpiperazin-1-yl)phenyl]-8-azabicyclo[3.2.1]octane

Base Information

Chemical Name:3-[4-(4-Methanesulfonylpiperazin-1-yl)phenyl]-8-azabicyclo[3.2.1]octane
CAS No.:1222495-66-0
Molecular Formula:C₁₈H₂₇N₃O₂S
Molecular Weight:349.497
Hs Code.:

Synonyms:3-[4-(4-Methanesulfonylpiperazin-1-yl)phenyl]-8-azabicyclo[3.2.1]octane

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Chemical Property of 3-[4-(4-Methanesulfonylpiperazin-1-yl)phenyl]-8-azabicyclo[3.2.1]octane

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Technology Process of 3-[4-(4-Methanesulfonylpiperazin-1-yl)phenyl]-8-azabicyclo[3.2.1]octane

There total 7 articles about 3-[4-(4-Methanesulfonylpiperazin-1-yl)phenyl]-8-azabicyclo[3.2.1]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1222495-64-8
3-[4-(4-methanesulfonylpiperazin-1-yl)phenyl]-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester

: 1222495-66-0
3-[4-(4-Methanesulfonylpiperazin-1-yl)phenyl]-8-azabicyclo[3.2.1]octane

Guidance literature:: 3-[4-(4-methanesulfonylpiperazin-1-yl)phenyl]-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester; With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 16h;

With sodium hydroxide; In water; pH=10;

Reference yield:

: 185099-67-6
Boc-tropinone

: 1222495-66-0
3-[4-(4-Methanesulfonylpiperazin-1-yl)phenyl]-8-azabicyclo[3.2.1]octane

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -70 °C / Inert atmosphere

1.2: 16 h / -70 - 20 °C / Inert atmosphere

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 6 h / Inert atmosphere; Reflux

3.1: hydrogen / palladium 10% on activated carbon / 2-methoxy-ethanol / 5 h / 25 °C / 1551.49 Torr

4.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 16 h / 20 °C

4.2: pH 10

With hydrogenchloride; hydrogen; potassium carbonate; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; 2-methoxy-ethanol; water;

Reference yield:

: 185099-68-7,1245646-51-8
tert‐butyl 3‐(trifluoromethanesulfonyloxy)‐8‐azabicyclo[3.2.1]oct‐2‐ene‐8‐carboxylate

: 1222495-66-0
3-[4-(4-Methanesulfonylpiperazin-1-yl)phenyl]-8-azabicyclo[3.2.1]octane

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 6 h / Inert atmosphere; Reflux

2.1: hydrogen / palladium 10% on activated carbon / 2-methoxy-ethanol / 5 h / 25 °C / 1551.49 Torr

3.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 16 h / 20 °C

3.2: pH 10

With hydrogenchloride; hydrogen; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; 2-methoxy-ethanol; water;