3-(3-Benzoyl-thioureido)-4-benzyl-1H-pyrrole-2-carboxylic acid methyl ester

Base Information

• Chemical Name: 3-(3-Benzoyl-thioureido)-4-benzyl-1H-pyrrole-2-carboxylic acid methyl ester
• CAS No.: 146386-03-0
• Molecular Formula: C₂₁H₁₉N₃O₃S
• Molecular Weight: 393.466
• Mol file: 146386-03-0.mol

Synonyms:3-(3-Benzoyl-thioureido)-4-benzyl-1H-pyrrole-2-carboxylic acid methyl ester

Chemical Property of 3-(3-Benzoyl-thioureido)-4-benzyl-1H-pyrrole-2-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3-Benzoyl-thioureido)-4-benzyl-1H-pyrrole-2-carboxylic acid methyl ester

There total 5 articles about 3-(3-Benzoyl-thioureido)-4-benzyl-1H-pyrrole-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methyl 3-amino-4-benzyl-1H-pyrrole-2-carboxylate (146385-89-9) + Benzoyl isothiocyanate (532-55-8) → 3-(3-Benzoyl-thioureido)-4-benzyl-1H-pyrrole-2-carboxylic acid methyl ester (146386-03-0)

Guidance literature:

In dichloromethane; for 1h; Ambient temperature;

DOI:10.1021/jm00053a008

Reference yield:

((Z)-2-Cyano-3-phenyl-propenylamino)-acetic acid methyl ester → 3-(3-Benzoyl-thioureido)-4-benzyl-1H-pyrrole-2-carboxylic acid methyl ester (146386-03-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1,5-diazabicyclo<4.3.0>non-5-ene (DBN) / CH₂Cl₂ / 24 h / Ambient temperature

2: Na₂CO₃ / methanol / 24 h / Ambient temperature

3: 95 percent / CH₂Cl₂ / 1 h / Ambient temperature

With DBN; sodium carbonate; In methanol; dichloromethane;

DOI:10.1021/jm00053a008

Reference yield:

3-Amino-4-benzyl-pyrrole-1,2-dicarboxylic acid 1-ethyl ester 2-methyl ester (1027489-15-1) → 3-(3-Benzoyl-thioureido)-4-benzyl-1H-pyrrole-2-carboxylic acid methyl ester (146386-03-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Na₂CO₃ / methanol / 24 h / Ambient temperature

2: 95 percent / CH₂Cl₂ / 1 h / Ambient temperature

With sodium carbonate; In methanol; dichloromethane;

DOI:10.1021/jm00053a008

upstream raw materials:

methyl 3-amino-4-benzyl-1H-pyrrole-2-carboxylate

Benzoyl isothiocyanate

3-Amino-4-benzyl-pyrrole-1,2-dicarboxylic acid 1-ethyl ester 2-methyl ester

dihydrocinnamonitrile

Downstream raw materials:

7-benzyl-2-(methylthio)-4-oxo-3H,5H-pyrrolo<3,2-d>pyrimidine

2-Amino-3,5-dihydro-7-(phenylmethyl)-4H-pyrrolo[3,2-d]pyrimidin-4-one

3-(3-Benzoyl-2-methyl-isothioureido)-4-benzyl-1H-pyrrole-2-carboxylic acid methyl ester