4-Fluoro-2-nitrobenzaldehyde

Base Information

• Chemical Name: 4-Fluoro-2-nitrobenzaldehyde
• CAS No.: 2923-96-8
• Molecular Formula: C7H4FNO3
• Molecular Weight: 169.112
• Hs Code.: 2913000090
• European Community (EC) Number: 220-884-3
• NSC Number: 96890
• UNII: UWH6CPQ66G
• DSSTox Substance ID: DTXSID40183487
• Nikkaji Number: J148.939I
• Wikidata: Q72475185
• Mol file: 2923-96-8.mol

Synonyms:4-Fluoro-2-nitrobenzaldehyde;2923-96-8;4-FLUORO-2-NITRO-BENZALDEHYDE;Benzaldehyde, 4-fluoro-2-nitro-;EINECS 220-884-3;MFCD01666439;NSC 96890;UWH6CPQ66G;BRN 1869008;2-Nitro-4-fluorobenzaldehyde;NSC-96890;NSC96890;UNII-UWH6CPQ66G;WLN: WNR CF FVH;SCHEMBL102898;4-fluoro-2-nitro benzaldehyde;DTXSID40183487;CL8354;AKOS006229124;AB09704;CS-W007758;GS-4322;SB36413;LS-25053;SY017029;A5473;AM20040113;FT-0647510;EN300-98407;J-515349;Z1198157443

Chemical Property of 4-Fluoro-2-nitrobenzaldehyde

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Melting Point: 32-33 °C
• Refractive Index: 1.59
• Boiling Point: 294.2 °C at 760 mmHg
• Flash Point: 131.7 °C
• PSA: 62.89000
• Density: 1.443 g/cm³
• LogP: 2.06960
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 169.01752115
• Heavy Atom Count: 12
• Complexity: 192

Purity/Quality:

97% ^*data from raw suppliers

4-Fluoro-2-nitrobenzaldehyde 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1F)[N+](=O)[O-])C=O

Technology Process of 4-Fluoro-2-nitrobenzaldehyde

There total 10 articles about 4-Fluoro-2-nitrobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2-nitro-4-fluorotoluene (446-10-6) → 4-fluoro-2-nitrobenzaldehyde (2923-96-8)

Guidance literature:

2-nitro-4-fluorotoluene; With pyrrolidine; N,N-dimethyl-formamide dimethyl acetal; In N,N-dimethyl-formamide; at 125 ℃; for 6h;

With sodium periodate; In tetrahydrofuran; water; at 0 - 20 ℃;

DOI:10.1016/j.ejmech.2017.11.057

Reference yield:

2-nitro-4-fluorotoluene (446-10-6) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → 4-fluoro-2-nitrobenzaldehyde (2923-96-8)

Guidance literature:

2-nitro-4-fluorotoluene; N,N-dimethyl-formamide dimethyl acetal; In N,N-dimethyl-formamide; at 135 ℃; for 20h;

With sodium periodate; In water; N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

N,N-dimethyl-2-(4-fluoro-2-nitrophenyl)ethenylamine (96631-90-2) → 4-fluoro-2-nitrobenzaldehyde (2923-96-8)

Guidance literature:

With sodium periodate; In aqueous THF;

upstream raw materials:

C₁₅H₁₄FN₃O₃

2-nitro-4-fluorotoluene

4-Fluor-2-nitro-1-diacetoxymethyl-benzol

p-fluorotoluene

Downstream raw materials:

1-(2'-Nitro-4'-fluorphenyl)-2-methyl-2-nitroethylen

ethyl 3-benzoylamino-6-(4-fluoro-6-nitrostyryl)-2-oxo-2H-pyran-5-carboxylate

7-Chloro-6-fluoro-10-hydroxy-3-(4-trifluoromethyl-phenyl)-3,4-dihydro-2H,10H-acridine-1,9-dione

(E)-2-Cyano-3-(4-fluoro-2-nitro-phenyl)-acrylamide