N-(2-((5aS,9aR)-1-(2,2-dimethoxyethyl)-4-methoxy-6-oxo-5a,6,7,9a-tetrahydrodibenzo[b,d]furan-9a-yl)ethyl)-N-methyl-2,4-dinitrobenzenesulfonamide

Base Information

Chemical Name:N-(2-((5aS,9aR)-1-(2,2-dimethoxyethyl)-4-methoxy-6-oxo-5a,6,7,9a-tetrahydrodibenzo[b,d]furan-9a-yl)ethyl)-N-methyl-2,4-dinitrobenzenesulfonamide
CAS No.:1315614-19-7
Molecular Formula:C₂₆H₂₉N₃O₁₁S
Molecular Weight:591.596
Hs Code.:

Synonyms:N-(2-((5aS,9aR)-1-(2,2-dimethoxyethyl)-4-methoxy-6-oxo-5a,6,7,9a-tetrahydrodibenzo[b,d]furan-9a-yl)ethyl)-N-methyl-2,4-dinitrobenzenesulfonamide

Suppliers and Price of N-(2-((5aS,9aR)-1-(2,2-dimethoxyethyl)-4-methoxy-6-oxo-5a,6,7,9a-tetrahydrodibenzo[b,d]furan-9a-yl)ethyl)-N-methyl-2,4-dinitrobenzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(2-((5aS,9aR)-1-(2,2-dimethoxyethyl)-4-methoxy-6-oxo-5a,6,7,9a-tetrahydrodibenzo[b,d]furan-9a-yl)ethyl)-N-methyl-2,4-dinitrobenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(2-((5aS,9aR)-1-(2,2-dimethoxyethyl)-4-methoxy-6-oxo-5a,6,7,9a-tetrahydrodibenzo[b,d]furan-9a-yl)ethyl)-N-methyl-2,4-dinitrobenzenesulfonamide

There total 16 articles about N-(2-((5aS,9aR)-1-(2,2-dimethoxyethyl)-4-methoxy-6-oxo-5a,6,7,9a-tetrahydrodibenzo[b,d]furan-9a-yl)ethyl)-N-methyl-2,4-dinitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1315614-18-6
N-(2-((5aS,6S,9aR)-1-(2,2-dimethoxyethyl)-4-methoxy-6-oxo-5a,6,7,9a-tetrahydrodibenzo[b,d]furan-9a-yl)ethyl)-N-methyl-2,4-dinitrobenzenesulfonamide

: 1315614-19-7
N-(2-((5aS,9aR)-1-(2,2-dimethoxyethyl)-4-methoxy-6-oxo-5a,6,7,9a-tetrahydrodibenzo[b,d]furan-9a-yl)ethyl)-N-methyl-2,4-dinitrobenzenesulfonamide

Guidance literature:: With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In ethyl acetate; at 80 ℃; for 3h; Inert atmosphere;
DOI:10.1139/v11-071

Reference yield:

: 621-59-0
isovanillin

: 1315614-19-7
N-(2-((5aS,9aR)-1-(2,2-dimethoxyethyl)-4-methoxy-6-oxo-5a,6,7,9a-tetrahydrodibenzo[b,d]furan-9a-yl)ethyl)-N-methyl-2,4-dinitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: N-Bromosuccinimide / chloroform / Inert atmosphere; Reflux

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere

3.1: tert.-butyl lithium / tetrahydrofuran / 0.42 h / -78 °C / Inert atmosphere

3.2: 3.58 h / 0 °C / Inert atmosphere; Reflux

4.1: toluene-4-sulfonic acid / tetrahydrofuran / 2 h / Inert atmosphere; Reflux

5.1: tributylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 4 - 25 °C / Inert atmosphere

6.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; potassium carbonate / toluene / 16 h / 110 °C / Inert atmosphere

6.2: 16 h / 0 - 25 °C / Inert atmosphere

7.1: trifluoroacetic acid / dichloromethane / 0.42 h / 0 °C / Inert atmosphere

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / Inert atmosphere

9.1: toluene-4-sulfonic acid / 72 h / Inert atmosphere; Reflux

10.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 3 h / 80 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; tributylphosphine; tri-tert-butyl phosphine; di-isopropyl azodicarboxylate; tert.-butyl lithium; potassium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dichloromethane; chloroform; ethyl acetate; toluene; 3.1: Wittig reaction / 3.2: Wittig reaction / 5.1: Mitsunobu reaction / 6.1: Heck coupling reaction;
DOI:10.1139/v11-071

Reference yield:

: 1315613-94-5
C₁₁H₁₇BrO₂

: 1315614-19-7
N-(2-((5aS,9aR)-1-(2,2-dimethoxyethyl)-4-methoxy-6-oxo-5a,6,7,9a-tetrahydrodibenzo[b,d]furan-9a-yl)ethyl)-N-methyl-2,4-dinitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium carbonate / tetrahydrofuran / 18.25 h / -40 - 25 °C / Inert atmosphere

2.1: hydrogenchloride / ethanol; water / 4 h / Inert atmosphere

3.1: ethanol; water / 4 h / Inert atmosphere

4.1: 1H-imidazole / dichloromethane / -78 - 25 °C / Inert atmosphere

5.1: tributylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 4 - 25 °C / Inert atmosphere

6.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; potassium carbonate / toluene / 16 h / 110 °C / Inert atmosphere

6.2: 16 h / 0 - 25 °C / Inert atmosphere

7.1: trifluoroacetic acid / dichloromethane / 0.42 h / 0 °C / Inert atmosphere

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / Inert atmosphere

9.1: toluene-4-sulfonic acid / 72 h / Inert atmosphere; Reflux

10.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 3 h / 80 °C / Inert atmosphere

With 1H-imidazole; hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tributylphosphine; tri-tert-butyl phosphine; di-isopropyl azodicarboxylate; potassium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; toluene; 5.1: Mitsunobu reaction / 6.1: Heck coupling reaction;
DOI:10.1139/v11-071