tert-butyl (S)-(1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

Base Information

• Chemical Name: tert-butyl (S)-(1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate
• CAS No.: 110625-79-1
• Molecular Formula: C₂₄H₂₆N₂O₅
• Molecular Weight: 422.481
• Mol file: 110625-79-1.mol

Synonyms:tert-butyl (S)-(1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

Chemical Property of tert-butyl (S)-(1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (S)-(1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

There total 2 articles about tert-butyl (S)-(1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

7-azido-4-methyl-2H-chromen-2-one + Boc-Phe-ONSu (3674-06-4) → tert-butyl (S)-(1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (110625-79-1)

Guidance literature:

Boc-Phe-ONSu; With sodium hydrogen selenide; In tetrahydrofuran; isopropyl alcohol; at 0 - 5 ℃; for 1h; Inert atmosphere;

7-azido-4-methyl-2H-chromen-2-one; In tetrahydrofuran; isopropyl alcohol; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.3762/bjoc.7.117

Reference yield:

7-azido-4-methyl-2H-chromen-2-one + C18H25NO6 (118517-06-9) → tert-butyl (S)-(1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (110625-79-1)

Guidance literature:

C₁₈H₂₅NO₆; With sodium hydrogen selenide; In tetrahydrofuran; toluene; at -15 - -10 ℃; for 0.583333h; Inert atmosphere;

7-azido-4-methyl-2H-chromen-2-one; In tetrahydrofuran; toluene; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.3762/bjoc.7.117

Reference yield:

tert-butyl (S)-(1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (110625-79-1) → H-Phe-NH-Mec (98516-72-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.abb.2016.10.007

upstream raw materials:

Boc-Phe-ONSu

C₁₈H₂₅NO₆

Downstream raw materials:

Gly-Phe-MCA

H-Phe-NH-Mec