[N-isobutyl-N'-({N'-[(N'-{[N-isobutyl-N'-({N'-[(N-isopropyl-hydrazino)-acetyl]-N-methyl-hydrazino}-acetyl)-hydrazino]-acetyl}-N-isopropyl-hydrazino)-acetyl]-N-methyl-hydrazino}-acetyl)-hydrazino]-acetic acid benzyl ester

Base Information

• Chemical Name: [N-isobutyl-N'-({N'-[(N'-{[N-isobutyl-N'-({N'-[(N-isopropyl-hydrazino)-acetyl]-N-methyl-hydrazino}-acetyl)-hydrazino]-acetyl}-N-isopropyl-hydrazino)-acetyl]-N-methyl-hydrazino}-acetyl)-hydrazino]-acetic acid benzyl ester
• CAS No.: 357953-62-9
• Molecular Formula: C₃₅H₆₄N₁₂O₇
• Molecular Weight: 764.969

Synonyms:[N-isobutyl-N'-({N'-[(N'-{[N-isobutyl-N'-({N'-[(N-isopropyl-hydrazino)-acetyl]-N-methyl-hydrazino}-acetyl)-hydrazino]-acetyl}-N-isopropyl-hydrazino)-acetyl]-N-methyl-hydrazino}-acetyl)-hydrazino]-acetic acid benzyl ester

Chemical Property of [N-isobutyl-N'-({N'-[(N'-{[N-isobutyl-N'-({N'-[(N-isopropyl-hydrazino)-acetyl]-N-methyl-hydrazino}-acetyl)-hydrazino]-acetyl}-N-isopropyl-hydrazino)-acetyl]-N-methyl-hydrazino}-acetyl)-hydrazino]-acetic acid benzyl ester

Chemical Property:

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Safty Information:

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Technology Process of [N-isobutyl-N'-({N'-[(N'-{[N-isobutyl-N'-({N'-[(N-isopropyl-hydrazino)-acetyl]-N-methyl-hydrazino}-acetyl)-hydrazino]-acetyl}-N-isopropyl-hydrazino)-acetyl]-N-methyl-hydrazino}-acetyl)-hydrazino]-acetic acid benzyl ester

There total 11 articles about [N-isobutyl-N'-({N'-[(N'-{[N-isobutyl-N'-({N'-[(N-isopropyl-hydrazino)-acetyl]-N-methyl-hydrazino}-acetyl)-hydrazino]-acetyl}-N-isopropyl-hydrazino)-acetyl]-N-methyl-hydrazino}-acetyl)-hydrazino]-acetic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

C40H72N12O9 (357953-72-1) → [N-isobutyl-N'-({N'-[(N'-{[N-isobutyl-N'-({N'-[(N-isopropyl-hydrazino)-acetyl]-N-methyl-hydrazino}-acetyl)-hydrazino]-acetyl}-N-isopropyl-hydrazino)-acetyl]-N-methyl-hydrazino}-acetyl)-hydrazino]-acetic acid benzyl ester (357953-62-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/jo001500d

Reference yield:

(N'-tert-butoxycarbonyl-N-isobutyl-hydrazino)-acetic acid benzyl ester (276672-44-7) → [N-isobutyl-N'-({N'-[(N'-{[N-isobutyl-N'-({N'-[(N-isopropyl-hydrazino)-acetyl]-N-methyl-hydrazino}-acetyl)-hydrazino]-acetyl}-N-isopropyl-hydrazino)-acetyl]-N-methyl-hydrazino}-acetyl)-hydrazino]-acetic acid benzyl ester (357953-62-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 78 percent / TFA / CH₂Cl₂ / 2 h / 20 °C

2: 93 percent / DMAP; DCC / CH₂Cl₂ / 12 h / 20 °C

3: 90 percent / TFA / CH₂Cl₂ / 2 h / 20 °C

4: 46 percent / DMAP; DCC / CH₂Cl₂ / 12 h / 20 °C

5: 95 percent / TFA / CH₂Cl₂ / 2 h / 20 °C

With dmap; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jo001500d

Reference yield:

Nα-i-Propyl-Nβ-Boc hydrazinoglycine methyl ester (276672-42-5) → [N-isobutyl-N'-({N'-[(N'-{[N-isobutyl-N'-({N'-[(N-isopropyl-hydrazino)-acetyl]-N-methyl-hydrazino}-acetyl)-hydrazino]-acetyl}-N-isopropyl-hydrazino)-acetyl]-N-methyl-hydrazino}-acetyl)-hydrazino]-acetic acid benzyl ester (357953-62-9)

Guidance literature:

Multi-step reaction with 7 steps

1: 65 percent / NaOH / acetonitrile; H₂O / 1.5 h / 20 °C

2: 67 percent / DMAP; DCC / CH₂Cl₂ / 12 h / 20 °C

3: 95 percent / H₂ / Pd/C / propan-2-ol / 18 h

4: 93 percent / DMAP; DCC / CH₂Cl₂ / 12 h / 20 °C

5: 90 percent / TFA / CH₂Cl₂ / 2 h / 20 °C

6: 46 percent / DMAP; DCC / CH₂Cl₂ / 12 h / 20 °C

7: 95 percent / TFA / CH₂Cl₂ / 2 h / 20 °C

With dmap; sodium hydroxide; hydrogen; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; water; isopropyl alcohol; acetonitrile;

DOI:10.1021/jo001500d

upstream raw materials:

C₄₀H₇₂N₁₂O₉

N^α-i-Propyl-N^β-Boc hydrazinoglycine methyl ester

(N'-tert-butoxycarbonyl-N-isopropyl-hydrazino)-acetic acid

(N-isobutyl-hydrazino)-acetic acid benzyl ester

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