(S)-3-((S)-1-Benzyloxycarbonyl-2-methyl-propylamino)-4,4,4-trifluoro-butyric acid

Base Information

• Chemical Name: (S)-3-((S)-1-Benzyloxycarbonyl-2-methyl-propylamino)-4,4,4-trifluoro-butyric acid
• CAS No.: 420110-67-4
• Molecular Formula: C₁₆H₂₀F₃NO₄
• Molecular Weight: 347.334

Synonyms:(S)-3-((S)-1-Benzyloxycarbonyl-2-methyl-propylamino)-4,4,4-trifluoro-butyric acid

Chemical Property of (S)-3-((S)-1-Benzyloxycarbonyl-2-methyl-propylamino)-4,4,4-trifluoro-butyric acid

Chemical Property:

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Technology Process of (S)-3-((S)-1-Benzyloxycarbonyl-2-methyl-propylamino)-4,4,4-trifluoro-butyric acid

There total 4 articles about (S)-3-((S)-1-Benzyloxycarbonyl-2-methyl-propylamino)-4,4,4-trifluoro-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

(S)-2-[(S)-3-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-1-trifluoromethyl-propylamino]-3-methyl-butyric acid benzyl ester (288577-16-2) → (S)-3-((S)-1-Benzyloxycarbonyl-2-methyl-propylamino)-4,4,4-trifluoro-butyric acid (420110-67-4)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; at 0 ℃; for 1h;

DOI:10.1021/ol005876p

Reference yield:

(S)-2-[3-((S)-4-Isopropyl-2-oxo-oxazolidin-3-yl)-3-oxo-1-trifluoromethyl-propylamino]-3-methyl-butyric acid benzyl ester → (S)-3-((S)-1-Benzyloxycarbonyl-2-methyl-propylamino)-4,4,4-trifluoro-butyric acid (420110-67-4)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; at 0 ℃; for 0.5h;

DOI:10.1021/ol005876p

Reference yield:

(S)-2-[(S)-3-((S)-4-Isopropyl-2-oxo-oxazolidin-3-yl)-3-oxo-1-trifluoromethyl-propylamino]-3-methyl-butyric acid benzyl ester (288577-17-3) → (S)-3-((S)-1-Benzyloxycarbonyl-2-methyl-propylamino)-4,4,4-trifluoro-butyric acid (420110-67-4)

Guidance literature:

With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1002/chem.200304881

upstream raw materials:

(S)-2-[(S)-3-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-1-trifluoromethyl-propylamino]-3-methyl-butyric acid benzyl ester

(S)-2-[(S)-3-((S)-4-Isopropyl-2-oxo-oxazolidin-3-yl)-3-oxo-1-trifluoromethyl-propylamino]-3-methyl-butyric acid benzyl ester

L-valine benzyl ester hydrochloride

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