6-phenyl-2-(thiophen-2-yl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde

Base Information

• Chemical Name: 6-phenyl-2-(thiophen-2-yl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde
• CAS No.: 884857-61-8
• Molecular Formula: C₁₅H₉N₃OS₂
• Molecular Weight: 311.388
• Mol file: 884857-61-8.mol

Synonyms:6-phenyl-2-(thiophen-2-yl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde

Chemical Property of 6-phenyl-2-(thiophen-2-yl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-phenyl-2-(thiophen-2-yl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde

There total 1 articles about 6-phenyl-2-(thiophen-2-yl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

6-phenyl-2-(thiophen-2-yl)imidazo[2,1-b][1,3,4]thiadiazole (73653-61-9) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 6-phenyl-2-(thiophen-2-yl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde (884857-61-8)

Guidance literature:

N,N-dimethyl-formamide; With trichlorophosphate; at -5 - 0 ℃; for 0.25h;

6-phenyl-2-(thiophen-2-yl)imidazo[2,1-b][1,3,4]thiadiazole; In N,N-dimethyl-formamide; at -5 - 65 ℃; for 6h;

DOI:10.1039/c9nj01100e

Reference yield: 83.0%

6-phenyl-2-(thiophen-2-yl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde (884857-61-8) → 6-phenyl-2-(thien-2-yl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde oxime

Guidance literature:

With pyridine; hydroxylamine hydrochloride; for 6h; Heating;

DOI:10.1016/j.bmc.2005.12.020

Reference yield: 76.0%

6-phenyl-2-(thiophen-2-yl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde (884857-61-8) + phenylacetonitrile (140-29-4) → (Z)-2-phenyl-3-(6-phenyl-2-(thiophen-2-yl)-imidazo[2,1-b][1,3,4]thiadiazol-5-yl)acrylonitrile

Guidance literature:

phenylacetonitrile; With sodium ethanolate; In ethanol; at 20 ℃; for 0.25h;

6-phenyl-2-(thiophen-2-yl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde; In ethanol; at 20 ℃; for 5h;

DOI:10.1039/c9nj01100e

upstream raw materials:

6-phenyl-2-(thiophen-2-yl)imidazo[2,1-b][1,3,4]thiadiazole

N,N-dimethyl-formamide