7-bromo-1-methyl-5-(4-(trifluoromethoxy)phenyl)-1,5-dihydro-4H-imidazo[4,5-c]pyridin-4-one

Base Information

Chemical Name:7-bromo-1-methyl-5-(4-(trifluoromethoxy)phenyl)-1,5-dihydro-4H-imidazo[4,5-c]pyridin-4-one
CAS No.:1590410-31-3
Molecular Formula:C₁₄H₉BrF₃N₃O₂
Molecular Weight:388.144
Hs Code.:

Synonyms:7-bromo-1-methyl-5-(4-(trifluoromethoxy)phenyl)-1,5-dihydro-4H-imidazo[4,5-c]pyridin-4-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-bromo-1-methyl-5-(4-(trifluoromethoxy)phenyl)-1,5-dihydro-4H-imidazo[4,5-c]pyridin-4-one

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 7-bromo-1-methyl-5-(4-(trifluoromethoxy)phenyl)-1,5-dihydro-4H-imidazo[4,5-c]pyridin-4-one

There total 5 articles about 7-bromo-1-methyl-5-(4-(trifluoromethoxy)phenyl)-1,5-dihydro-4H-imidazo[4,5-c]pyridin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.6%

: 1-methyl-5-(4-(trifluoromethoxy)phenyl)-1,5-dihydro-4H-imidazo[4,5-c]pyridin-4-one

: 1590410-31-3
7-bromo-1-methyl-5-(4-(trifluoromethoxy)phenyl)-1,5-dihydro-4H-imidazo[4,5-c]pyridin-4-one

Guidance literature:: With N-Bromosuccinimide; sulfuric acid; In water; at 0 - 22 ℃;

Reference yield:

: 1239719-69-7
2 -chloro-N-methyl-3-nitropyridin-4-amine

: 1590410-31-3
7-bromo-1-methyl-5-(4-(trifluoromethoxy)phenyl)-1,5-dihydro-4H-imidazo[4,5-c]pyridin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: 2 % platinum on carbon; hydrogen / water; tetrahydrofuran / 20 - 30 °C / 1500.15 Torr / Autoclave

2: 6 h / Reflux

3: copper(II) acetate hydrate; potassium carbonate; 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole / 1-methyl-pyrrolidin-2-one / 0.2 - 150 °C / Inert atmosphere

4: sulfuric acid; N-Bromosuccinimide / water / 0 - 22 °C

With N-Bromosuccinimide; copper(II) acetate hydrate; sulfuric acid; 2 % platinum on carbon; hydrogen; potassium carbonate; 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; water;

Reference yield:

: 73685-97-9
1-methyl-1,5-dihydro-4H-imidazo[4,5-c]pyridin-4-one

: 1590410-31-3
7-bromo-1-methyl-5-(4-(trifluoromethoxy)phenyl)-1,5-dihydro-4H-imidazo[4,5-c]pyridin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: copper(II) acetate hydrate; potassium carbonate; 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole / 1-methyl-pyrrolidin-2-one / 0.2 - 150 °C / Inert atmosphere

2: sulfuric acid; N-Bromosuccinimide / water / 0 - 22 °C

With N-Bromosuccinimide; copper(II) acetate hydrate; sulfuric acid; potassium carbonate; 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; In 1-methyl-pyrrolidin-2-one; water;