3-(1,3-benzodioxol-5-yl)-1-(4-methoxyphenyl)-5(-furan-2-yl)-1H-pyrazole

Base Information

Chemical Name:3-(1,3-benzodioxol-5-yl)-1-(4-methoxyphenyl)-5(-furan-2-yl)-1H-pyrazole
CAS No.:1235344-45-2
Molecular Formula:C₂₁H₁₆N₂O₄
Molecular Weight:360.369
Hs Code.:

Synonyms:3-(1,3-benzodioxol-5-yl)-1-(4-methoxyphenyl)-5(-furan-2-yl)-1H-pyrazole

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Chemical Property of 3-(1,3-benzodioxol-5-yl)-1-(4-methoxyphenyl)-5(-furan-2-yl)-1H-pyrazole

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Technology Process of 3-(1,3-benzodioxol-5-yl)-1-(4-methoxyphenyl)-5(-furan-2-yl)-1H-pyrazole

There total 5 articles about 3-(1,3-benzodioxol-5-yl)-1-(4-methoxyphenyl)-5(-furan-2-yl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1235344-25-8
3-bromo-5-(furan-2-yl)-1-(4-methoxyphenyl)-1H-pyrazole

: 94839-07-3
3,4-(methylenedioxy)-benzeneboronic acid

: 1235344-45-2
3-(1,3-benzodioxol-5-yl)-1-(4-methoxyphenyl)-5(-furan-2-yl)-1H-pyrazole

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 50 ℃; for 3h; Inert atmosphere;
DOI:10.1002/ejoc.201100119

Reference yield:

: 3815-80-3
3-(p-anisyl)sydnone

: 1235344-45-2
3-(1,3-benzodioxol-5-yl)-1-(4-methoxyphenyl)-5(-furan-2-yl)-1H-pyrazole

Guidance literature:: Multi-step reaction with 5 steps

1: sodium acetate; Iodine monochloride; acetic acid

2: 5,5-dimethyl-1,3-cyclohexadiene / Reflux

3: sulfuric acid; water / 0.5 h / 180 °C

4: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 50 °C / Inert atmosphere

5: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 3 h / 50 °C / Inert atmosphere

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; water; sodium acetate; Iodine monochloride; acetic acid; In 5,5-dimethyl-1,3-cyclohexadiene; water; N,N-dimethyl-formamide; 4: Suzuki-type cross coupling / 5: Suzuki cross-coupling reaction;
DOI:10.1002/ejoc.201100119

Reference yield:

: 1235344-12-3
ethyl 3-bromo-5-iodo-1-(4-methoxyphenyl)-1H-pyrazole-4-carboxylate

: 1235344-45-2
3-(1,3-benzodioxol-5-yl)-1-(4-methoxyphenyl)-5(-furan-2-yl)-1H-pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid; water / 0.5 h / 180 °C

2: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 50 °C / Inert atmosphere

3: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 3 h / 50 °C / Inert atmosphere

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; water; In water; N,N-dimethyl-formamide; 2: Suzuki-type cross coupling / 3: Suzuki cross-coupling reaction;
DOI:10.1002/ejoc.201100119