diethyl (4R)-[3-O-acetyl-2-O-benzoyl-1-deoxy-1-(thymin-1-yl)-α-D-threofuranos-4-yl]phoshonate

Base Information

Chemical Name:diethyl (4R)-[3-O-acetyl-2-O-benzoyl-1-deoxy-1-(thymin-1-yl)-α-D-threofuranos-4-yl]phoshonate
CAS No.:1333476-10-0
Molecular Formula:C₂₂H₂₇N₂O₁₀P
Molecular Weight:510.438
Hs Code.:

Synonyms:diethyl (4R)-[3-O-acetyl-2-O-benzoyl-1-deoxy-1-(thymin-1-yl)-α-D-threofuranos-4-yl]phoshonate

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Chemical Property of diethyl (4R)-[3-O-acetyl-2-O-benzoyl-1-deoxy-1-(thymin-1-yl)-α-D-threofuranos-4-yl]phoshonate

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Technology Process of diethyl (4R)-[3-O-acetyl-2-O-benzoyl-1-deoxy-1-(thymin-1-yl)-α-D-threofuranos-4-yl]phoshonate

There total 8 articles about diethyl (4R)-[3-O-acetyl-2-O-benzoyl-1-deoxy-1-(thymin-1-yl)-α-D-threofuranos-4-yl]phoshonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1333476-08-6
diethyl (4R)-(1,3-di-O-acetyl-2-O-benzoyl-α-D-threofuranos-4-yl)phosphonate

: 116165-26-5
5-Methyl-1-trimethylsilanyl-1H-pyrimidine-2,4-dione

: 1333476-10-0
diethyl (4R)-[3-O-acetyl-2-O-benzoyl-1-deoxy-1-(thymin-1-yl)-α-D-threofuranos-4-yl]phoshonate

Guidance literature:: With tin(IV) chloride; In acetonitrile; at -10 - 20 ℃; Inert atmosphere;
DOI:10.1135/cccc2011038

Reference yield:

: C₁₅H₂₁O₈P

: 1333476-10-0
diethyl (4R)-[3-O-acetyl-2-O-benzoyl-1-deoxy-1-(thymin-1-yl)-α-D-threofuranos-4-yl]phoshonate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap / pyridine / 0.5 h

2: tin(IV) chloride / acetonitrile / -10 - 20 °C / Inert atmosphere

With dmap; tin(IV) chloride; In pyridine; acetonitrile;
DOI:10.1135/cccc2011038

Reference yield:

: diethyl (5R)-(3-O-benzoyl-1,2-O-isopropylidene-α-D-xylofuranos-5-C-yl)phosphonate

: 1333476-10-0
diethyl (4R)-[3-O-acetyl-2-O-benzoyl-1-deoxy-1-(thymin-1-yl)-α-D-threofuranos-4-yl]phoshonate

Guidance literature:: Multi-step reaction with 3 steps

1: periodic acid dihydrate / 1,4-dioxane; water / 48 h / 50 °C / Darkness

2: dmap / pyridine / 0.5 h

3: tin(IV) chloride / acetonitrile / -10 - 20 °C / Inert atmosphere

With dmap; periodic acid dihydrate; tin(IV) chloride; In 1,4-dioxane; pyridine; water; acetonitrile;
DOI:10.1135/cccc2011038