4-(6,7-bis(2-(methoxy-d3)ethoxy-d4)quinazolin-4-ylamino)-2-ethynylphenol

Base Information

Chemical Name:4-(6,7-bis(2-(methoxy-d3)ethoxy-d4)quinazolin-4-ylamino)-2-ethynylphenol
CAS No.:1188417-68-6
Molecular Formula:C₂₂H₂₃N₃O₅
Molecular Weight:423.331
Hs Code.:

Synonyms:4-(6,7-bis(2-(methoxy-d3)ethoxy-d4)quinazolin-4-ylamino)-2-ethynylphenol

Suppliers and Price of 4-(6,7-bis(2-(methoxy-d3)ethoxy-d4)quinazolin-4-ylamino)-2-ethynylphenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-(6,7-bis(2-(methoxy-d3)ethoxy-d4)quinazolin-4-ylamino)-2-ethynylphenol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(6,7-bis(2-(methoxy-d3)ethoxy-d4)quinazolin-4-ylamino)-2-ethynylphenol

There total 7 articles about 4-(6,7-bis(2-(methoxy-d3)ethoxy-d4)quinazolin-4-ylamino)-2-ethynylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₂₁⁽²⁾H₁₀N₃O₅Si

: 1188417-68-6
4-(6,7-bis(2-(methoxy-d3)ethoxy-d4)quinazolin-4-ylamino)-2-ethynylphenol

Guidance literature:: With methanol; potassium carbonate; In chloroform; at 20 ℃; for 4h;

Reference yield:

: 89487-91-2
2-iodo-4-nitrophenol

: 1188417-68-6
4-(6,7-bis(2-(methoxy-d3)ethoxy-d4)quinazolin-4-ylamino)-2-ethynylphenol

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 1,4-dioxane / 2 h / 20 °C

2.1: tin(II) chloride dihdyrate / ethanol / 2 h / Reflux

2.2: pH 8 / Alkaline solution

3.1: chloroform / 4 h / Reflux

4.1: methanol; potassium carbonate / chloroform / 4 h / 20 °C

With methanol; tin(II) chloride dihdyrate; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In 1,4-dioxane; ethanol; chloroform; 1.1: Sonogashira Coupling;

Reference yield:

: 1188417-63-1
(6,7-bis(2-(methoxy-d3)-2,2-d2-ethoxy)-4-oxoquinazolin-3(4H)-yl)methyl pivalate

: 1188417-68-6
4-(6,7-bis(2-(methoxy-d3)ethoxy-d4)quinazolin-4-ylamino)-2-ethynylphenol

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonia / methanol / 20 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / chloroform / 6.25 h / 0 °C / Reflux

2.2: Saturated solution

3.1: chloroform / 4 h / Reflux

4.1: methanol; potassium carbonate / chloroform / 4 h / 20 °C

With methanol; oxalyl dichloride; ammonia; potassium carbonate; N,N-dimethyl-formamide; In methanol; chloroform;