2-(2-bromo-5-fluorophenyl)pyrrolidine

Base Information

• Chemical Name: 2-(2-bromo-5-fluorophenyl)pyrrolidine
• CAS No.: 1016533-55-3
• Molecular Formula: C₁₀H₁₁BrFN
• Molecular Weight: 244.106
• Mol file: 1016533-55-3.mol

Synonyms:2-(2-bromo-5-fluorophenyl)pyrrolidine

Chemical Property of 2-(2-bromo-5-fluorophenyl)pyrrolidine

Chemical Property:

Purity/Quality:

2-(2-bromo-5-fluorophenyl)pyrrolidine 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-bromo-5-fluorophenyl)pyrrolidine

There total 2 articles about 2-(2-bromo-5-fluorophenyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-iodo-3-chloro-propane (6940-76-7) + (E)-N-(2-bromo-5-fluorobenzylidene)-1,1-diphenylmethanamine (1224945-41-8) → 2-(2-bromo-5-fluorophenyl)pyrrolidine (1016533-55-3)

Guidance literature:

(E)-N-(2-bromo-5-fluorobenzylidene)-1,1-diphenylmethanamine; With potassium tert-butylate; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

1-iodo-3-chloro-propane; In tetrahydrofuran; at 0 ℃;

Reference yield:

2-(2-bromo-5-fluorophenyl)pyrrolidine hydrochloride → 2-(2-bromo-5-fluorophenyl)pyrrolidine (1016533-55-3)

Guidance literature:

With water; sodium hydroxide; at 20 ℃;

upstream raw materials:

1-iodo-3-chloro-propane

(E)-N-(2-bromo-5-fluorobenzylidene)-1,1-diphenylmethanamine

Refernces

• 1、 -. "( PYRROLIDIN-2 -YL) PHENYL DERIVATIVES FOR USE IN THE TREATMENT OF PAIN". Page/Page column 20-21. . Retrieved 2010/06/11.