N-(2,2-diphenyl-ethyl)-N'-{11-[5-formyl-2-(2-trimethylsilanyl-ethoxymethoxy)-phenoxy]-undecyl}-succinamide

Base Information

• Chemical Name: N-(2,2-diphenyl-ethyl)-N'-{11-[5-formyl-2-(2-trimethylsilanyl-ethoxymethoxy)-phenoxy]-undecyl}-succinamide
• CAS No.: 689271-66-7
• Molecular Formula: C₄₂H₆₀N₂O₆Si
• Molecular Weight: 717.034
• Mol file: 689271-66-7.mol

Synonyms:N-(2,2-diphenyl-ethyl)-N'-{11-[5-formyl-2-(2-trimethylsilanyl-ethoxymethoxy)-phenoxy]-undecyl}-succinamide

Chemical Property of N-(2,2-diphenyl-ethyl)-N'-{11-[5-formyl-2-(2-trimethylsilanyl-ethoxymethoxy)-phenoxy]-undecyl}-succinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2,2-diphenyl-ethyl)-N'-{11-[5-formyl-2-(2-trimethylsilanyl-ethoxymethoxy)-phenoxy]-undecyl}-succinamide

There total 1 articles about N-(2,2-diphenyl-ethyl)-N'-{11-[5-formyl-2-(2-trimethylsilanyl-ethoxymethoxy)-phenoxy]-undecyl}-succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3-hydroxy-4-(2-trimethylsilylethoxymethoxy)benzaldehyde (110466-10-9) + N-(2,2-diphenyl-ethyl)-N'-(11-hydroxy-undecyl)-succinamide → N-(2,2-diphenyl-ethyl)-N'-{11-[5-formyl-2-(2-trimethylsilanyl-ethoxymethoxy)-phenoxy]-undecyl}-succinamide (689271-66-7)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine;

DOI:10.1002/anie.200353248

Reference yield: 85.0%

diethyl (2,2-diphenylethylcarbamoyl)-methyl phosphonate (689271-68-9) + N-(2,2-diphenyl-ethyl)-N'-{11-[5-formyl-2-(2-trimethylsilanyl-ethoxymethoxy)-phenoxy]-undecyl}-succinamide (689271-66-7) → N-(2,2-diphenyl-ethyl)-N'-{11-[5-[2-(2,2-diphenyl-ethylcarbamoyl)-vinyl]-2-(2-trimethylsilanyl-ethoxymethoxy)-phenoxy]-undecyl}-succinamide (689271-69-0)

Guidance literature:

With sodium hydride; In tetrahydrofuran;

DOI:10.1002/anie.200353248

Reference yield:

N-(2,2-diphenyl-ethyl)-N'-{11-[5-formyl-2-(2-trimethylsilanyl-ethoxymethoxy)-phenoxy]-undecyl}-succinamide (689271-66-7) → N-(2,2-diphenyl-ethyl)-N'-(11-{5-[2-(2,2-diphenyl-ethylcarbamoyl)-vinyl]-2-hydroxy-phenoxy}-undecyl)-succinamide

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / NaH / tetrahydrofuran

2: 61 percent / TBAF; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; 4 Angstroem molecular sieves

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; 4 A molecular sieve; tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran;

DOI:10.1002/anie.200353248

upstream raw materials:

3-hydroxy-4-(2-trimethylsilylethoxymethoxy)benzaldehyde

Downstream raw materials:

N-(2,2-diphenyl-ethyl)-N'-{11-[5-[2-(2,2-diphenyl-ethylcarbamoyl)-vinyl]-2-(2-trimethylsilanyl-ethoxymethoxy)-phenoxy]-undecyl}-succinamide