tert-butyl 5-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-3-[(1S)-2-hydroxy-1-methylethyl]-2-(3,4,5-trimethylphenyl)-1H-indole-1-carboxylate

Base Information

Chemical Name:tert-butyl 5-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-3-[(1S)-2-hydroxy-1-methylethyl]-2-(3,4,5-trimethylphenyl)-1H-indole-1-carboxylate
CAS No.:357193-16-9
Molecular Formula:C₃₅H₄₆N₂O₄
Molecular Weight:558.761
Hs Code.:

tert-butyl 5-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-3-[(1S)-2-hydroxy-1-methylethyl]-2-(3,4,5-trimethylphenyl)-1H-indole-1-carboxylate

Synonyms:tert-butyl 5-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-3-[(1S)-2-hydroxy-1-methylethyl]-2-(3,4,5-trimethylphenyl)-1H-indole-1-carboxylate

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Chemical Property of tert-butyl 5-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-3-[(1S)-2-hydroxy-1-methylethyl]-2-(3,4,5-trimethylphenyl)-1H-indole-1-carboxylate

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Technology Process of tert-butyl 5-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-3-[(1S)-2-hydroxy-1-methylethyl]-2-(3,4,5-trimethylphenyl)-1H-indole-1-carboxylate

There total 15 articles about tert-butyl 5-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-3-[(1S)-2-hydroxy-1-methylethyl]-2-(3,4,5-trimethylphenyl)-1H-indole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: C₄₄H₅₄N₂O₃

: 357193-16-9
tert-butyl 5-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-3-[(1S)-2-hydroxy-1-methylethyl]-2-(3,4,5-trimethylphenyl)-1H-indole-1-carboxylate

Guidance literature:: C₄₄H₅₄N₂O₃; With 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide; In 1,4-dioxane; water; tert-butyl alcohol; at 10 ℃; for 12h;

With sodium tetrahydroborate; In methanol; at 20 ℃; for 0.5h;
DOI:10.1002/anie.201300785

Reference yield:

: 357193-15-8
tert-butyl 5-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-3-[(1S)-2-(benzyloxy)-1-methylethyl]-2-(3,4,5-trimethylphenyl)-1H-indole-1-carboxylate

: 357193-16-9
tert-butyl 5-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-3-[(1S)-2-hydroxy-1-methylethyl]-2-(3,4,5-trimethylphenyl)-1H-indole-1-carboxylate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 3h; under 2068.59 Torr;
DOI:10.1016/S0040-4020(01)00367-2

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 357193-16-9
tert-butyl 5-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-3-[(1S)-2-hydroxy-1-methylethyl]-2-(3,4,5-trimethylphenyl)-1H-indole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: DMAP / CH₂Cl₂ / 2 h / 20 °C

2: 2.155 g / H₂ / 10 percent Pd/C / ethanol / 3 h / 20 °C / 2068.59 Torr

With dmap; hydrogen; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/S0040-4020(01)00367-2