Ethyl loflazepate

Base Information

• Chemical Name: Ethyl loflazepate
• CAS No.: 29177-84-2
• Molecular Formula: C18H14 Cl F N2 O3
• Molecular Weight: 360.772
• European Community (EC) Number: 249-489-4
• UNII: VJB5FW9W9J
• DSSTox Substance ID: DTXSID60865475
• Nikkaji Number: J21.650J
• Wikipedia: Ethyl_loflazepate
• Wikidata: Q5404460
• NCI Thesaurus Code: C65566
• Metabolomics Workbench ID: 146193
• ChEMBL ID: CHEMBL1213460
• Mol file: 29177-84-2.mol

Synonyms:CM 6912;ethyl flucozepate;ethyl loflazepate;Victan

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Chemical Property of Ethyl loflazepate

Chemical Property:

• Vapor Pressure: 1.98E-10mmHg at 25°C
• Melting Point: 193-194°
• Boiling Point: 507.7°Cat760mmHg
• PKA: 10.56±0.70(Predicted)
• Flash Point: 260.9°C
• PSA: 67.76000
• Density: 1.39g/cm³
• LogP: 2.77390
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 360.0676982
• Heavy Atom Count: 25
• Complexity: 556

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1C(=O)NC2=C(C=C(C=C2)Cl)C(=N1)C3=CC=CC=C3F
• Uses: A new benzodiazepine derivative as a new anti-anxiety drug. Ethyl Loflazepate and its metabolite were compared with those of Diazepam (D416855), Nitrazepam (N490140) and Lorazepam (L469850). The anticonflict effect of Ethyl Loflazepate was slightly more potent than that of Diazepam and much more potent than that of Lorazepam. Controlled substance.
• Therapeutic Function: Tranquilizer

Technology Process of Ethyl loflazepate

There total 1 articles about Ethyl loflazepate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 7-chloro-3-ethoxycarbonyl-5-(2-fluorophenyl)-2-oxo-2,3-dihydro-1H-1,4-benzodiazepine (29177-84-2,158251-55-9,158251-58-2)

Guidance literature:

s.a. Bsp.10;