Valnivudine

Base Information

Chemical Name:Valnivudine
CAS No.:956483-02-6
Molecular Formula:C₂₇H₃₅N₃O₆
Molecular Weight:497.591
Hs Code.:
UNII:0NJ5F6D4U7
ChEMBL ID:CHEMBL4300944
DSSTox Substance ID:DTXSID30241909
NCI Thesaurus Code:C152817
Wikidata:Q27237002
Mol file:956483-02-6.mol

Synonyms:3-(2-deoxy-b-D-ribofuranosyl)-6-(p-pentylphenyl)-2,3-dihydrofuro(2,3-d)pyrimidin-2-one, 50-valyl ester, HCl salt;FV-100

Suppliers and Price of Valnivudine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
FV100(freebase)
2.5mg
$ 165.00

Medical Isotopes, Inc.
FV100(freebase)
2.5 mg
$ 450.00

ChemScene
Valnivudine 98.02%
25mg
$ 1800.00

ChemScene
Valnivudine 98.02%
10mg
$ 850.00

ChemScene
Valnivudine 98.02%
5mg
$ 500.00

Total 7 raw suppliers

Chemical Property of Valnivudine

Chemical Property:

XLogP3:4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:11
Exact Mass:497.25258584
Heavy Atom Count:36
Complexity:905

Purity/Quality:

97% ^*data from raw suppliers

FV100(freebase) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCC1=CC=C(C=C1)C2=CC3=CN(C(=O)N=C3O2)C4CC(C(O4)COC(=O)C(C(C)C)N)O
Isomeric SMILES:CCCCCC1=CC=C(C=C1)C2=CC3=CN(C(=O)N=C3O2)[C@H]4C[C@@H]([C@H](O4)COC(=O)[C@H](C(C)C)N)O
Uses FV-100 is an orally available nucleoside analogue prodrug of CF-1743 (C291710) which is used for the treatment of herpes zoster, or shingles, which is an infection caused by the reactivation of varicella zoster virus or VZV.

Technology Process of Valnivudine

There total 9 articles about Valnivudine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: (S)-((2R,3S,5R)-3-(benzyloxycarbonyloxy)-5-(2-oxo-6-(4-pentylphenyl)furo[2,3-d]pyrimidin-3(2H)-yl)-tetrahydrofuran-2-yl)methyl 2-(benzyloxycarbonylamino)-3-methylbutanoate

: 956483-02-6
FV-100

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethyl acetate; at 20 ℃; for 2h; under 13446.2 Torr;

Reference yield: 90.0%

: 1269409-87-1
3-[2'-deoxy-5'-O-[N-(fluorenylmethoxycarbonyl)valyl]-β-D-ribofuranosyl]-6-(p-pentylphenyl)-2,3-dihydrofuro[2,3-d]pyrimidin-2-one

: 956483-02-6
FV-100

Guidance literature:: 3-[2'-deoxy-5'-O-[N-(fluorenylmethoxycarbonyl)valyl]-β-D-ribofuranosyl]-6-(p-pentylphenyl)-2,3-dihydrofuro[2,3-d]pyrimidin-2-one; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 2h;

With hydrogenchloride; In dichloromethane; isopropyl alcohol; at 5 ℃; pH=1 - 4;

Reference yield: 55.0%

: 68858-20-8
Fmoc-Val-OH

: CF-1743

: 956483-02-6
FV-100

Guidance literature:: CF-1743; With di-tert-butyl-diazodicarboxylate; In N,N-dimethyl-formamide; for 0.333333h;

Fmoc-Val-OH; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

With piperidine; In N,N-dimethyl-formamide; for 0.166667h;