1'-benzyl-3,4-dihydro-7-methoxyspiro(naphthalene-1-(2H),4'-piperidine)

Base Information

• Chemical Name: 1'-benzyl-3,4-dihydro-7-methoxyspiro(naphthalene-1-(2H),4'-piperidine)
• CAS No.: 134697-79-3
• Molecular Formula: C₂₂H₂₇NO
• Molecular Weight: 321.462
• Mol file: 134697-79-3.mol

Synonyms:1'-benzyl-3,4-dihydro-7-methoxyspiro(naphthalene-1-(2H),4'-piperidine)

Chemical Property of 1'-benzyl-3,4-dihydro-7-methoxyspiro(naphthalene-1-(2H),4'-piperidine)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1'-benzyl-3,4-dihydro-7-methoxyspiro(naphthalene-1-(2H),4'-piperidine)

There total 3 articles about 1'-benzyl-3,4-dihydro-7-methoxyspiro(naphthalene-1-(2H),4'-piperidine) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

1'-benzyl-3,4-dihydro-7-methoxy-2-oxospiro (134697-67-9) → 1'-benzyl-3,4-dihydro-7-hydroxyspiro(naphthalene-1-(2H),4'-piperidine) (134698-13-8) + 1'-benzyl-3,4-dihydro-7-methoxyspiro(naphthalene-1-(2H),4'-piperidine) (134697-79-3)

Guidance literature:

With potassium hydroxide; hydrazine hydrate; In diethylene glycol; for 7h; Heating;

DOI:10.1021/jm00089a013

Reference yield:

7-methoxyl-2-tetralone (4133-34-0) → 1'-benzyl-3,4-dihydro-7-methoxyspiro(naphthalene-1-(2H),4'-piperidine) (134697-79-3)

Guidance literature:

Multi-step reaction with 2 steps

1: KO-t-Bu / 2-methyl-propan-2-ol; dimethylsulfoxide

2: 49 percent / KOH, hydrazine hydrate / bis-(2-hydroxy-ethyl) ether / 7 h / Heating

With potassium hydroxide; potassium tert-butylate; hydrazine hydrate; In dimethyl sulfoxide; tert-butyl alcohol; diethylene glycol;

DOI:10.1021/jm00089a013

Reference yield:

N,N-bis(2-chloro-ethyl)-benzenemethanamine (55-51-6) → 1'-benzyl-3,4-dihydro-7-methoxyspiro(naphthalene-1-(2H),4'-piperidine) (134697-79-3)

Guidance literature:

Multi-step reaction with 2 steps

1: KO-t-Bu / 2-methyl-propan-2-ol; dimethylsulfoxide

2: 49 percent / KOH, hydrazine hydrate / bis-(2-hydroxy-ethyl) ether / 7 h / Heating

With potassium hydroxide; potassium tert-butylate; hydrazine hydrate; In dimethyl sulfoxide; tert-butyl alcohol; diethylene glycol;

DOI:10.1021/jm00089a013

upstream raw materials:

1'-benzyl-3,4-dihydro-7-methoxy-2-oxospiro

7-methoxyl-2-tetralone

N,N-bis(2-chloro-ethyl)-benzenemethanamine