3,3′-(2-iodo-5-((4-(methoxycarbonyl)phenyl)ethynyl)-1,4-phenylene)bis(oxy)bis(propane-3,1-diyl) diacetate

Base Information

Chemical Name:3,3′-(2-iodo-5-((4-(methoxycarbonyl)phenyl)ethynyl)-1,4-phenylene)bis(oxy)bis(propane-3,1-diyl) diacetate
CAS No.:1338725-53-3
Molecular Formula:C₂₆H₂₇IO₈
Molecular Weight:594.4
Hs Code.:

Synonyms:3,3′-(2-iodo-5-((4-(methoxycarbonyl)phenyl)ethynyl)-1,4-phenylene)bis(oxy)bis(propane-3,1-diyl) diacetate

Suppliers and Price of 3,3′-(2-iodo-5-((4-(methoxycarbonyl)phenyl)ethynyl)-1,4-phenylene)bis(oxy)bis(propane-3,1-diyl) diacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3,3′-(2-iodo-5-((4-(methoxycarbonyl)phenyl)ethynyl)-1,4-phenylene)bis(oxy)bis(propane-3,1-diyl) diacetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3,3′-(2-iodo-5-((4-(methoxycarbonyl)phenyl)ethynyl)-1,4-phenylene)bis(oxy)bis(propane-3,1-diyl) diacetate

There total 3 articles about 3,3′-(2-iodo-5-((4-(methoxycarbonyl)phenyl)ethynyl)-1,4-phenylene)bis(oxy)bis(propane-3,1-diyl) diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 3034-86-4
4-ethynylbenzoic acid methyl ester

: 3,3′-(2,5-diiodo-1,4-phenylene)bis(oxy)bis(propane-3,1-diyl) diacetate

: 1338725-53-3
3,3′-(2-iodo-5-((4-(methoxycarbonyl)phenyl)ethynyl)-1,4-phenylene)bis(oxy)bis(propane-3,1-diyl) diacetate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; at 20 ℃; for 12h;
DOI:10.1007/s10895-013-1286-7

Reference yield:

: 123-31-9,8027-02-9
hydroquinone

: 1338725-53-3
3,3′-(2-iodo-5-((4-(methoxycarbonyl)phenyl)ethynyl)-1,4-phenylene)bis(oxy)bis(propane-3,1-diyl) diacetate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / Inert atmosphere; Reflux

2: dmap; pyridine / dichloromethane / 20 °C / Inert atmosphere

3: iodine; potassium iodate; sulfuric acid; acetic acid / water / 12 h / 60 °C

4: 1,8-diazabicyclo[5.4.0]undec-7-ene; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / toluene / 12 h / 20 °C

With pyridine; dmap; bis-triphenylphosphine-palladium(II) chloride; potassium iodate; copper(l) iodide; sulfuric acid; iodine; potassium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; water; toluene; acetonitrile; 4: |Sonogashira Cross-Coupling;
DOI:10.1007/s10895-013-1286-7

Reference yield:

: 15497-91-3
3,3′-(1,4-phenylenebis(oxy))dipropan-1-ol

: 1338725-53-3
3,3′-(2-iodo-5-((4-(methoxycarbonyl)phenyl)ethynyl)-1,4-phenylene)bis(oxy)bis(propane-3,1-diyl) diacetate

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; pyridine / dichloromethane / 20 °C / Inert atmosphere

2: iodine; potassium iodate; sulfuric acid; acetic acid / water / 12 h / 60 °C

3: 1,8-diazabicyclo[5.4.0]undec-7-ene; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / toluene / 12 h / 20 °C

With pyridine; dmap; bis-triphenylphosphine-palladium(II) chloride; potassium iodate; copper(l) iodide; sulfuric acid; iodine; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; water; toluene; 3: |Sonogashira Cross-Coupling;
DOI:10.1007/s10895-013-1286-7