tert-butyl N-{2-(2-aminopyridin-3-yl)-5-[2-(4-fluorophenyl)ethynyl]-1,3-thiazol-4-yl}carbamate

Base Information

Chemical Name:tert-butyl N-{2-(2-aminopyridin-3-yl)-5-[2-(4-fluorophenyl)ethynyl]-1,3-thiazol-4-yl}carbamate
CAS No.:1258934-83-6
Molecular Formula:C₂₁H₁₉FN₄O₂S
Molecular Weight:410.472
Hs Code.:

Synonyms:tert-butyl N-{2-(2-aminopyridin-3-yl)-5-[2-(4-fluorophenyl)ethynyl]-1,3-thiazol-4-yl}carbamate

Suppliers and Price of tert-butyl N-{2-(2-aminopyridin-3-yl)-5-[2-(4-fluorophenyl)ethynyl]-1,3-thiazol-4-yl}carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl N-{2-(2-aminopyridin-3-yl)-5-[2-(4-fluorophenyl)ethynyl]-1,3-thiazol-4-yl}carbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl N-{2-(2-aminopyridin-3-yl)-5-[2-(4-fluorophenyl)ethynyl]-1,3-thiazol-4-yl}carbamate

There total 2 articles about tert-butyl N-{2-(2-aminopyridin-3-yl)-5-[2-(4-fluorophenyl)ethynyl]-1,3-thiazol-4-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1204112-62-8
3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine

: 1258934-81-4
tert-butyl N-{2-chloro-5-[2-(4-fluorophenyl)ethynyl]-1,3-thiazol-4-yl}carbamate

: 1258934-83-6
tert-butyl N-{2-(2-aminopyridin-3-yl)-5-[2-(4-fluorophenyl)ethynyl]-1,3-thiazol-4-yl}carbamate

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; at 85 ℃; for 24h; Inert atmosphere; sealed vessel;
DOI:10.1055/s-0030-1258159

Reference yield:

: 1258934-83-6
tert-butyl N-{2-(2-aminopyridin-3-yl)-5-[2-(4-fluorophenyl)ethynyl]-1,3-thiazol-4-yl}carbamate

Guidance literature:

Reference yield: 47.0%

: 1258934-83-6
tert-butyl N-{2-(2-aminopyridin-3-yl)-5-[2-(4-fluorophenyl)ethynyl]-1,3-thiazol-4-yl}carbamate

: 1258934-92-7
3-[5-(4-fluorophenyl)-4H-pyrrolo[2,3-d]thiazol-2-yl]pyridin-2-ylamine

Guidance literature:: With potassium tert-butylate; In 1-methyl-pyrrolidin-2-one; at 90 ℃; for 0.25h; Microwave irradiation; Inert atmosphere; sealed tube;
DOI:10.1055/s-0030-1258159