3-Chloromethyl-1-(3,5-dichloro-phenyl)-azetidine-3-carboxylic acid isopropyl ester

Base Information

Chemical Name:3-Chloromethyl-1-(3,5-dichloro-phenyl)-azetidine-3-carboxylic acid isopropyl ester
CAS No.:137267-00-6
Molecular Formula:C₁₄H₁₆Cl₃NO₂
Molecular Weight:336.646
Hs Code.:

Synonyms:3-Chloromethyl-1-(3,5-dichloro-phenyl)-azetidine-3-carboxylic acid isopropyl ester

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Chemical Property of 3-Chloromethyl-1-(3,5-dichloro-phenyl)-azetidine-3-carboxylic acid isopropyl ester

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Technology Process of 3-Chloromethyl-1-(3,5-dichloro-phenyl)-azetidine-3-carboxylic acid isopropyl ester

There total 7 articles about 3-Chloromethyl-1-(3,5-dichloro-phenyl)-azetidine-3-carboxylic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 2,2-Bis-chloromethyl-N-(3,5-dichloro-phenyl)-3-isopropoxy-propionamide

: 137267-00-6
3-Chloromethyl-1-(3,5-dichloro-phenyl)-azetidine-3-carboxylic acid isopropyl ester

Guidance literature:: With tetra-(n-butyl)ammonium iodide; triethylamine; at 100 - 160 ℃;
DOI:10.1016/S0040-4039(00)92310-4

Reference yield:

: 115-77-5
Pentaerythritol

: 137267-00-6
3-Chloromethyl-1-(3,5-dichloro-phenyl)-azetidine-3-carboxylic acid isopropyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: SOCl₂, pyridine

2: conc. HNO₃

3: SOCl₂

5: 40percent aq. NaOH / Bu₄NBr / CH₂Cl₂

6: ethanol / 2 h / Heating

7: 70 percent / Et₃N, Bu₄NI / 100 - 160 °C

With pyridine; sodium hydroxide; thionyl chloride; nitric acid; tetra-(n-butyl)ammonium iodide; triethylamine; tetrabutylammomium bromide; In ethanol; dichloromethane;
DOI:10.1016/S0040-4039(00)92310-4

Reference yield:

: 813-99-0
3-chloro-(2,2-chloromethyl)propan-1-ol

: 137267-00-6
3-Chloromethyl-1-(3,5-dichloro-phenyl)-azetidine-3-carboxylic acid isopropyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: conc. HNO₃

2: SOCl₂

4: 40percent aq. NaOH / Bu₄NBr / CH₂Cl₂

5: ethanol / 2 h / Heating

6: 70 percent / Et₃N, Bu₄NI / 100 - 160 °C

With sodium hydroxide; thionyl chloride; nitric acid; tetra-(n-butyl)ammonium iodide; triethylamine; tetrabutylammomium bromide; In ethanol; dichloromethane;
DOI:10.1016/S0040-4039(00)92310-4