(Z)-N,N-diethyl-{N^α-[2-(phenyldimethylsilyl)but-2-enyl]}phenylglycine amide

Base Information

Chemical Name:(Z)-N,N-diethyl-{N^α-[2-(phenyldimethylsilyl)but-2-enyl]}phenylglycine amide
CAS No.:524696-70-6
Molecular Formula:C₂₄H₃₄N₂OSi
Molecular Weight:394.632
Hs Code.:

(Z)-N,N-diethyl-{N<sup>α</sup>-[2-(phenyldimethylsilyl)but-2-enyl]}phenylglycine amide

Synonyms:(Z)-N,N-diethyl-{N^α-[2-(phenyldimethylsilyl)but-2-enyl]}phenylglycine amide

Suppliers and Price of (Z)-N,N-diethyl-{N^α-[2-(phenyldimethylsilyl)but-2-enyl]}phenylglycine amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-N,N-diethyl-{N^α-[2-(phenyldimethylsilyl)but-2-enyl]}phenylglycine amide

Chemical Property:

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Technology Process of (Z)-N,N-diethyl-{N^α-[2-(phenyldimethylsilyl)but-2-enyl]}phenylglycine amide

There total 4 articles about (Z)-N,N-diethyl-{N^α-[2-(phenyldimethylsilyl)but-2-enyl]}phenylglycine amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 55610-31-6
N,N-diethylphenylglycine amide

: 320618-66-4
1-bromo-2-(dimethylphenylsilanyl)but-2(E)-ene

: 524696-70-6
(Z)-N,N-diethyl-{N^α-[2-(phenyldimethylsilyl)but-2-enyl]}phenylglycine amide

Guidance literature:: With potassium carbonate; In acetonitrile; at 3 ℃; for 14h;
DOI:10.1039/b207295e

Reference yield:

: 2900-27-8,3601-66-9,14675-97-9,33125-05-2
2-(tert-butoxycarbonylamino)-2-phenylacetic acid

: 524696-70-6
(Z)-N,N-diethyl-{N^α-[2-(phenyldimethylsilyl)but-2-enyl]}phenylglycine amide

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / tetrahydrofuran / 0.67 h / -30 °C

2: 3.78 g / tetrahydrofuran / 1.87 h / -30 - 20 °C

3: 97 percent / TFA / CH₂Cl₂ / 2 h / 20 °C

4: 99 percent / K₂CO₃ / acetonitrile / 14 h / 3 °C

With potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1039/b207295e

Reference yield:

: 524696-63-7
tert-butyl 2-(diethylamino)-2-oxo-1-phenylethylcarbamate

: 524696-70-6
(Z)-N,N-diethyl-{N^α-[2-(phenyldimethylsilyl)but-2-enyl]}phenylglycine amide

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / TFA / CH₂Cl₂ / 2 h / 20 °C

2: 99 percent / K₂CO₃ / acetonitrile / 14 h / 3 °C

With potassium carbonate; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1039/b207295e