(2R,3S)-3-hydroxy-2-[({[(1s,4s)-4-benzylcyclohexyl]oxy}carbonyl)amino]butanoic acid

Base Information

Chemical Name:(2R,3S)-3-hydroxy-2-[({[(1s,4s)-4-benzylcyclohexyl]oxy}carbonyl)amino]butanoic acid
CAS No.:1439367-69-7
Molecular Formula:C₁₈H₂₅NO₅
Molecular Weight:335.4
Hs Code.:

Synonyms:(2R,3S)-3-hydroxy-2-[({[(1s,4s)-4-benzylcyclohexyl]oxy}carbonyl)amino]butanoic acid

Suppliers and Price of (2R,3S)-3-hydroxy-2-[({[(1s,4s)-4-benzylcyclohexyl]oxy}carbonyl)amino]butanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3S)-3-hydroxy-2-[({[(1s,4s)-4-benzylcyclohexyl]oxy}carbonyl)amino]butanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3S)-3-hydroxy-2-[({[(1s,4s)-4-benzylcyclohexyl]oxy}carbonyl)amino]butanoic acid

There total 7 articles about (2R,3S)-3-hydroxy-2-[({[(1s,4s)-4-benzylcyclohexyl]oxy}carbonyl)amino]butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1659-31-0
2,2'-dipyridyl carbonate

: 632-20-2,134357-96-3,7013-32-3,82822-12-6
D-Threonine

: 1411975-91-1,1411975-97-7,1453805-03-2
4-benzylidenecyclohexanol

: 1439367-70-0
(2R,3S)-3-hydroxy-2-[({[(1s,4s)-4-benzylcyclohexyl]oxy}carbonyl)amino]butanoic acid

: 1439367-69-7
(2R,3S)-3-hydroxy-2-[({[(1s,4s)-4-benzylcyclohexyl]oxy}carbonyl)amino]butanoic acid

Guidance literature:: 2,2'-dipyridyl carbonate; 4-benzylidenecyclohexanol; With dmap; In dichloromethane; at 20 ℃; for 15h; Inert atmosphere;

D-Threonine; With sodium hydrogencarbonate; In tetrahydrofuran; water; at 20 ℃; for 15h; Overall yield = 0.4 g;

Reference yield:

: 1659-31-0
2,2'-dipyridyl carbonate

: 632-20-2,134357-96-3,7013-32-3,82822-12-6
D-Threonine

: 176972-48-8
4-benzylcyclohexanol

: 1439367-70-0
(2R,3S)-3-hydroxy-2-[({[(1s,4s)-4-benzylcyclohexyl]oxy}carbonyl)amino]butanoic acid

: 1439367-69-7
(2R,3S)-3-hydroxy-2-[({[(1s,4s)-4-benzylcyclohexyl]oxy}carbonyl)amino]butanoic acid

Guidance literature:: 2,2'-dipyridyl carbonate; 4-benzylcyclohexanol; With dmap; In dichloromethane; at 20 ℃; for 15h; Inert atmosphere;

D-Threonine; With sodium hydrogencarbonate; In tetrahydrofuran; water; at 20 ℃; for 15h; Overall yield = 0.4 mg; Optical yield = 20 %de;
DOI:10.1021/jm400739u

Reference yield:

: 1449-46-3
benzyltriphenylphosphonium bromide

: 1439367-69-7
(2R,3S)-3-hydroxy-2-[({[(1s,4s)-4-benzylcyclohexyl]oxy}carbonyl)amino]butanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 1 h / 20 - 50 °C / Inert atmosphere

1.2: 16 h / 50 °C / Inert atmosphere

2.1: hydrogenchloride / acetone / 4 h / 20 °C / Inert atmosphere

3.1: sodium tetrahydroborate / methanol / 1 h / 0 °C / Inert atmosphere

4.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 30 °C / 750.08 Torr

5.1: dmap / dichloromethane / 15 h / 20 °C / Inert atmosphere

5.2: 15 h / 20 °C

With hydrogenchloride; dmap; sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; sodium hydride; In methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; acetone; mineral oil; 1.1: |Wittig Olefination;
DOI:10.1021/jm400739u