Dimethyl 5-(1,1,2,2-tetrafluoro-2-bromoethoxy)isophthalate

Base Information

• Chemical Name: Dimethyl 5-(1,1,2,2-tetrafluoro-2-bromoethoxy)isophthalate
• CAS No.: 252975-66-9
• Molecular Formula: C₁₂H₉BrF₄O₅
• Molecular Weight: 389.098
• Mol file: 252975-66-9.mol

Synonyms:Dimethyl 5-(1,1,2,2-tetrafluoro-2-bromoethoxy)isophthalate

Chemical Property of Dimethyl 5-(1,1,2,2-tetrafluoro-2-bromoethoxy)isophthalate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of Dimethyl 5-(1,1,2,2-tetrafluoro-2-bromoethoxy)isophthalate

There total 1 articles about Dimethyl 5-(1,1,2,2-tetrafluoro-2-bromoethoxy)isophthalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

1,2-dibromo-1,1,2,2-tetrafluoroethane (124-73-2) + Dimethyl 5-hydroxyisophthalate (13036-02-7) → Dimethyl 5-(1,1,2,2-tetrafluoro-2-bromoethoxy)isophthalate (252975-66-9)

Guidance literature:

Dimethyl 5-hydroxyisophthalate; With potassium methanolate; In methanol; at 0 - 20 ℃;

1,2-dibromo-1,1,2,2-tetrafluoroethane; In dimethyl sulfoxide; at 75 - 85 ℃; for 4h;

DOI:10.1016/S0022-1139(00)00308-0

Reference yield:

Dimethyl 5-(1,1,2,2-tetrafluoro-2-bromoethoxy)isophthalate (252975-66-9) → sodium; 2-(3,5-bis-methoxycarbonyl-phenoxy)-1,1,2,2-tetrafluoro-ethanesulfinate

Guidance literature:

With sodium dithionite; sodium hydrogencarbonate; In N,N-dimethyl-formamide; Heating;

DOI:10.1016/S0022-1139(00)00308-0

Reference yield:

Dimethyl 5-(1,1,2,2-tetrafluoro-2-bromoethoxy)isophthalate (252975-66-9) → 5-(2-chlorosulfonyl-1,1,2,2-tetrafluoro-ethoxy)-isophthalic acid dimethyl ester (252975-67-0)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. Na₂S₂O₄; NaHCO₃ / dimethylformamide / Heating

2: 257.4 g / Cl₂; H₂O / 1,1,2-trichloro-1,2,2-trifluoro-ethane

With sodium dithionite; water; chlorine; sodium hydrogencarbonate; In 1,1,2-Trichloro-1,2,2-trifluoroethane; N,N-dimethyl-formamide; 1: Substitution / 2: Substitution;

DOI:10.1016/S0022-1139(00)00308-0

upstream raw materials:

1,2-dibromo-1,1,2,2-tetrafluoroethane

Dimethyl 5-hydroxyisophthalate

Downstream raw materials:

5-(2-chlorosulfonyl-1,1,2,2-tetrafluoro-ethoxy)-isophthalic acid dimethyl ester