(R,E)-3-(4-amino-1-(1-(4-(4-(2-aminoethyl)piperazin-1-yl)but-2-enoyl)piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-isopropylphenyl)benzamide hydrochloride

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Chemical Name:(R,E)-3-(4-amino-1-(1-(4-(4-(2-aminoethyl)piperazin-1-yl)but-2-enoyl)piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-isopropylphenyl)benzamide hydrochloride
CAS No.:1407966-97-5
Molecular Formula:C₃₆H₄₆N₁₀O₂*ClH
Molecular Weight:687.288
Hs Code.:

(R,E)-3-(4-amino-1-(1-(4-(4-(2-aminoethyl)piperazin-1-yl)but-2-enoyl)piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-isopropylphenyl)benzamide hydrochloride

Synonyms:(R,E)-3-(4-amino-1-(1-(4-(4-(2-aminoethyl)piperazin-1-yl)but-2-enoyl)piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-isopropylphenyl)benzamide hydrochloride

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Chemical Property of (R,E)-3-(4-amino-1-(1-(4-(4-(2-aminoethyl)piperazin-1-yl)but-2-enoyl)piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-isopropylphenyl)benzamide hydrochloride

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Technology Process of (R,E)-3-(4-amino-1-(1-(4-(4-(2-aminoethyl)piperazin-1-yl)but-2-enoyl)piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-isopropylphenyl)benzamide hydrochloride

There total 4 articles about (R,E)-3-(4-amino-1-(1-(4-(4-(2-aminoethyl)piperazin-1-yl)but-2-enoyl)piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-isopropylphenyl)benzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1407967-22-9
C₄₁H₅₄N₁₀O₄

: 1407966-97-5
(R,E)-3-(4-amino-1-(1-(4-(4-(2-aminoethyl)piperazin-1-yl)but-2-enoyl)piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-isopropylphenyl)benzamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 0 ℃; for 2h;
DOI:10.1021/jm301190s

Reference yield:

: 99-88-7
4-Isopropylaniline

: 1407966-97-5
(R,E)-3-(4-amino-1-(1-(4-(4-(2-aminoethyl)piperazin-1-yl)but-2-enoyl)piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-isopropylphenyl)benzamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.5 h

1.2: 0.5 h

2.1: hydrogenchloride / 1,4-dioxane / 0.5 h / Reflux

3.1: triethylamine / dichloromethane / 0.08 h / 0 °C

3.2: 1 h

4.1: triethylamine / tetrahydrofuran / 20 °C

5.1: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 0 °C

With hydrogenchloride; triethylamine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm301190s

Reference yield:

: 1407967-09-2
3-{4-amino-3-[3-(4-isopropylphenylcarbamoyl)phenyl]pyrazolo[3,4-d]pyrimidin-1-yl}piperidine-1-carboxylic acid tert-butyl ester

: 1407966-97-5
(R,E)-3-(4-amino-1-(1-(4-(4-(2-aminoethyl)piperazin-1-yl)but-2-enoyl)piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-isopropylphenyl)benzamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / 1,4-dioxane / 0.5 h / Reflux

2.1: triethylamine / dichloromethane / 0.08 h / 0 °C

2.2: 1 h

3.1: triethylamine / tetrahydrofuran / 20 °C

4.1: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 0 °C

With hydrogenchloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm301190s