Technology Process of C21H12F8O4
There total 4 articles about C21H12F8O4 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-vinyl-2,3,5,6-tetrafluorobenzylalcohol; malonoyl dichloride;
With
dmap; triethylamine;
In
dichloromethane;
at 0 ℃;
Reflux;
With
water;
In
dichloromethane;
DOI:10.1016/j.jfluchem.2011.07.021
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium / diethyl ether / -20 - 0 °C / Inert atmosphere
1.2: 20 °C / Inert atmosphere
2.1: hydrogenchloride; trifluoroacetic acid / water / 3 h / 60 °C
3.1: sodium tetrahydroborate / methanol / 20 °C / Cooling with ice
4.1: dmap; triethylamine / dichloromethane / 0 °C / Reflux
With
hydrogenchloride; dmap; sodium tetrahydroborate; n-butyllithium; triethylamine; trifluoroacetic acid;
In
methanol; diethyl ether; dichloromethane; water;
DOI:10.1016/j.jfluchem.2011.07.021
- Guidance literature:
-
Multi-step reaction with 3 steps
1: hydrogenchloride; trifluoroacetic acid / water / 3 h / 60 °C
2: sodium tetrahydroborate / methanol / 20 °C / Cooling with ice
3: dmap; triethylamine / dichloromethane / 0 °C / Reflux
With
hydrogenchloride; dmap; sodium tetrahydroborate; triethylamine; trifluoroacetic acid;
In
methanol; dichloromethane; water;
DOI:10.1016/j.jfluchem.2011.07.021
