(R)-N-((R)-2-Cyclohexylcarbamoyl-1-methyl-ethoxy)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxy)-butyramide

Base Information

Chemical Name:(R)-N-((R)-2-Cyclohexylcarbamoyl-1-methyl-ethoxy)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxy)-butyramide
CAS No.:795300-73-1
Molecular Formula:C₂₂H₂₉N₃O₆
Molecular Weight:431.489
Hs Code.:

Synonyms:(R)-N-((R)-2-Cyclohexylcarbamoyl-1-methyl-ethoxy)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxy)-butyramide

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Chemical Property of (R)-N-((R)-2-Cyclohexylcarbamoyl-1-methyl-ethoxy)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxy)-butyramide

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Technology Process of (R)-N-((R)-2-Cyclohexylcarbamoyl-1-methyl-ethoxy)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxy)-butyramide

There total 3 articles about (R)-N-((R)-2-Cyclohexylcarbamoyl-1-methyl-ethoxy)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxy)-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 3-aminooxy-N-cyclohexyl-butyramide

: 795300-69-5
(R)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yloxy)-butyric acid

: 795300-73-1
(R)-N-((R)-2-Cyclohexylcarbamoyl-1-methyl-ethoxy)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxy)-butyramide

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1021/jo049174f

Reference yield:

: 795300-67-3
2-((R)-3-Hydroxy-1-methyl-propoxy)-isoindole-1,3-dione

: 795300-73-1
(R)-N-((R)-2-Cyclohexylcarbamoyl-1-methyl-ethoxy)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxy)-butyramide

Guidance literature:: Multi-step reaction with 2 steps

1: aq. NaIO₄; RuO₂*xH₂O / acetonitrile; CCl₄; acetone / 5 h / 20 °C

2: 54 percent / EDCI; 1-hydroxy-7-azabenzotriazole / CH₂Cl₂ / 20 °C

With ruthenium(IV) oxide; sodium periodate; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrachloromethane; dichloromethane; acetone; acetonitrile;
DOI:10.1021/jo049174f

Reference yield:

: 795300-71-9
N-cyclohexyl-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxy)-butyramide

: 795300-73-1
(R)-N-((R)-2-Cyclohexylcarbamoyl-1-methyl-ethoxy)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxy)-butyramide

Guidance literature:: Multi-step reaction with 2 steps

1: NH₂NH₂*H₂O / methanol; CH₂Cl₂ / 1.5 h / 20 °C

2: 54 percent / EDCI; 1-hydroxy-7-azabenzotriazole / CH₂Cl₂ / 20 °C

With 1-hydroxy-7-aza-benzotriazole; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;
DOI:10.1021/jo049174f