4,5-dihydro-3-(2-hydroxyphenyl)isoxazole-5-carboxylic acid 4-(sec-butyl)phenylamide

Base Information

Chemical Name:4,5-dihydro-3-(2-hydroxyphenyl)isoxazole-5-carboxylic acid 4-(sec-butyl)phenylamide
CAS No.:1235471-24-5
Molecular Formula:C₂₀H₂₂N₂O₃
Molecular Weight:338.406
Hs Code.:

Synonyms:4,5-dihydro-3-(2-hydroxyphenyl)isoxazole-5-carboxylic acid 4-(sec-butyl)phenylamide

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Chemical Property of 4,5-dihydro-3-(2-hydroxyphenyl)isoxazole-5-carboxylic acid 4-(sec-butyl)phenylamide

Chemical Property:

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Technology Process of 4,5-dihydro-3-(2-hydroxyphenyl)isoxazole-5-carboxylic acid 4-(sec-butyl)phenylamide

There total 5 articles about 4,5-dihydro-3-(2-hydroxyphenyl)isoxazole-5-carboxylic acid 4-(sec-butyl)phenylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: C₁₀H₈ClNO₃

: 30273-11-1,181288-08-4
4-sec-butylaniline

: 1235471-24-5
4,5-dihydro-3-(2-hydroxyphenyl)isoxazole-5-carboxylic acid 4-(sec-butyl)phenylamide

Guidance literature:: With triethylamine; In toluene; at 20 ℃; Reflux;
DOI:10.1007/s00706-010-0265-9

Reference yield:

: 119841-74-6
N,2-dihydroxybenzenecarbonimidoyl chloride

: 1235471-24-5
4,5-dihydro-3-(2-hydroxyphenyl)isoxazole-5-carboxylic acid 4-(sec-butyl)phenylamide

Guidance literature:: Multi-step reaction with 4 steps

1: magnesium sulfate; triethylamine / toluene / 20 °C

2: water; sodium hydroxide / ethanol

3: oxalyl dichloride / benzene

4: triethylamine / toluene / 20 °C / Reflux

With oxalyl dichloride; water; magnesium sulfate; triethylamine; sodium hydroxide; In ethanol; toluene; benzene;
DOI:10.1007/s00706-010-0265-9

Reference yield:

: 165532-43-4
ethyl 4,5-dihydro-3-(2-hydroxyphenyl)isoxazole-5-carboxylate

: 1235471-24-5
4,5-dihydro-3-(2-hydroxyphenyl)isoxazole-5-carboxylic acid 4-(sec-butyl)phenylamide

Guidance literature:: Multi-step reaction with 3 steps

1: water; sodium hydroxide / ethanol

2: oxalyl dichloride / benzene

3: triethylamine / toluene / 20 °C / Reflux

With oxalyl dichloride; water; triethylamine; sodium hydroxide; In ethanol; toluene; benzene;
DOI:10.1007/s00706-010-0265-9