N^α,N^δ,N^ω-tris(benzyloxycarbonyl)-L-arginyl-N-methyl-L-norleucyl-L-aspartic acid β-cyclohexyl-α-tert-butyl ester

Base Information

• Chemical Name: N^α,N^δ,N^ω-tris(benzyloxycarbonyl)-L-arginyl-N-methyl-L-norleucyl-L-aspartic acid β-cyclohexyl-α-tert-butyl ester
• CAS No.: 151012-07-6
• Molecular Formula: C₅₁H₆₈N₆O₁₂
• Molecular Weight: 957.134

Synonyms:N^α,N^δ,N^ω-tris(benzyloxycarbonyl)-L-arginyl-N-methyl-L-norleucyl-L-aspartic acid β-cyclohexyl-α-tert-butyl ester

Chemical Property of N^α,N^δ,N^ω-tris(benzyloxycarbonyl)-L-arginyl-N-methyl-L-norleucyl-L-aspartic acid β-cyclohexyl-α-tert-butyl ester

Chemical Property:

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Technology Process of N^α,N^δ,N^ω-tris(benzyloxycarbonyl)-L-arginyl-N-methyl-L-norleucyl-L-aspartic acid β-cyclohexyl-α-tert-butyl ester

There total 6 articles about N^α,N^δ,N^ω-tris(benzyloxycarbonyl)-L-arginyl-N-methyl-L-norleucyl-L-aspartic acid β-cyclohexyl-α-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Nα,Nδ,Nω-tris(benzyloxycarbonyl)-L-arginine (14611-34-8) → Nα,Nδ,Nω-tris(benzyloxycarbonyl)-L-arginyl-N-methyl-L-norleucyl-L-aspartic acid β-cyclohexyl-α-tert-butyl ester (151012-07-6)

Guidance literature:

Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 0.33 h

2: Et₃N / CH₂Cl₂ / 4 h / Ambient temperature

3: 89 percent / TFA / CH₂Cl₂ / 0.67 h

4: 1.) HOBT, DCC, 2.) N-methylmorpholine / 1.) CH₂Cl₂, a) -10 deg C, 20 min, b) RT, 20 min, 2.) CH₂Cl₂, overnight

With 4-methyl-morpholine; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jm950803a

Reference yield:

N-BOC-N-methylnorleucine (117903-25-0) → Nα,Nδ,Nω-tris(benzyloxycarbonyl)-L-arginyl-N-methyl-L-norleucyl-L-aspartic acid β-cyclohexyl-α-tert-butyl ester (151012-07-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) conc. H₂SO₄ / 1.) dioxane, 15 min, 2.) dioxane, 5 h

2: Et₃N / CH₂Cl₂ / 4 h / Ambient temperature

3: 89 percent / TFA / CH₂Cl₂ / 0.67 h

4: 1.) HOBT, DCC, 2.) N-methylmorpholine / 1.) CH₂Cl₂, a) -10 deg C, 20 min, b) RT, 20 min, 2.) CH₂Cl₂, overnight

With 4-methyl-morpholine; sulfuric acid; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jm950803a

Reference yield:

C35H40N4O10 → Nα,Nδ,Nω-tris(benzyloxycarbonyl)-L-arginyl-N-methyl-L-norleucyl-L-aspartic acid β-cyclohexyl-α-tert-butyl ester (151012-07-6)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 4 h / Ambient temperature

2: 89 percent / TFA / CH₂Cl₂ / 0.67 h

3: 1.) HOBT, DCC, 2.) N-methylmorpholine / 1.) CH₂Cl₂, a) -10 deg C, 20 min, b) RT, 20 min, 2.) CH₂Cl₂, overnight

With 4-methyl-morpholine; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jm950803a

upstream raw materials:

N^α,N^δ,N^ω-tris(benzyloxycarbonyl)-L-arginyl-N-methylnorleucine

N^α,N^δ,N^ω-tris(benzyloxycarbonyl)-L-arginine

N-BOC-N-methylnorleucine

N-methylnorleucine tert-butyl ester

Downstream raw materials:

N^α,N^δ,N^ω-tris(benzyloxycarbonyl)-L-arginyl-N-methyl-L-norleucyl-L-aspartic acid β-cyclohexyl ester

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