Technology Process of 3-(benzyloxy)-3-ethynyl-2-methylene-tetrahydro-2H-pyran
There total 4 articles about 3-(benzyloxy)-3-ethynyl-2-methylene-tetrahydro-2H-pyran which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
(triphenylphosphine)gold(I) chloride; silver tetrafluoroborate;
In
tetrahydrofuran;
at 20 ℃;
for 2h;
regioselective reaction;
Inert atmosphere;
DOI:10.1021/ol102628x
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 1H-imidazole / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
4.1: (triphenylphosphine)gold(I) chloride; silver tetrafluoroborate / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
With
1H-imidazole; (triphenylphosphine)gold(I) chloride; silver tetrafluoroborate; tetrabutyl ammonium fluoride; sodium hydride;
In
tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ol102628x
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
3.1: (triphenylphosphine)gold(I) chloride; silver tetrafluoroborate / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
With
(triphenylphosphine)gold(I) chloride; silver tetrafluoroborate; tetrabutyl ammonium fluoride; sodium hydride;
In
tetrahydrofuran; mineral oil;
DOI:10.1021/ol102628x
