Technology Process of (+/-)-4-bromo-2-(3-hydroxy-1-phenylpropyl)phenol
There total 1 articles about (+/-)-4-bromo-2-(3-hydroxy-1-phenylpropyl)phenol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
6-bromo-4-phenyl-3,4-dihydro-2H-chromen-2-one;
With
sodium tetrahydroborate;
In
tetrahydrofuran;
at 0 - 35 ℃;
Industry scale;
With
hydrogenchloride;
In
water;
at 5 - 30 ℃;
pH=1 - 2;
Industry scale;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: potassium carbonate / acetone / 20 - 25 °C / Industry scale
1.2: 50 - 60 °C
2.1: pyridine / dichloromethane / 5 - 30 °C / Industry scale
3.1: water / 75 - 78 °C / Industry scale
4.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 50 - 60 °C
4.2: -70 - -60 °C
4.3: -50 °C
5.1: borane-dimethyl sulfide complex / tetrahydrofuran / 25 - 50 °C
5.2: 0.5 h / 10 - 15 °C / Industry scale
6.1: raney nickel / methanol / 30 - 35 °C / Autoclave
7.1: tetrahydrofuran / 10 - 55 °C
8.1: potassium carbonate / toluene; water / 50 - 55 °C
9.1: dichloromethane / -25 - -20 °C
With
pyridine; ethyl bromide; borane-dimethyl sulfide complex; iodine; potassium carbonate; magnesium;
raney nickel;
In
tetrahydrofuran; methanol; dichloromethane; water; acetone; toluene;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: potassium carbonate / acetone / 20 - 25 °C / Industry scale
1.2: 50 - 60 °C
2.1: pyridine / dichloromethane / 5 - 30 °C / Industry scale
3.1: water / 75 - 78 °C / Industry scale
4.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 50 - 60 °C
4.2: -70 - -60 °C
4.3: -50 °C
5.1: borane-dimethyl sulfide complex / tetrahydrofuran / 25 - 50 °C
5.2: 0.5 h / 10 - 15 °C / Industry scale
6.1: raney nickel / methanol / 30 - 35 °C / Autoclave
7.1: tetrahydrofuran / 10 - 55 °C
8.1: potassium carbonate / toluene; water / 50 - 55 °C
With
pyridine; ethyl bromide; borane-dimethyl sulfide complex; iodine; potassium carbonate; magnesium;
raney nickel;
In
tetrahydrofuran; methanol; dichloromethane; water; acetone; toluene;
