(2S,3R,4S)-2-({[(dimethylamino)carbonyl]-L-phenylalanyl-L-histidyl}amino)-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

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Chemical Name:(2S,3R,4S)-2-({[(dimethylamino)carbonyl]-L-phenylalanyl-L-histidyl}amino)-1-cyclohexyl-3,4-dihydroxy-6-methylheptane
CAS No.:114457-18-0
Molecular Formula:C₃₂H₅₀N₆O₅
Molecular Weight:598.786
Hs Code.:

Synonyms:(2S,3R,4S)-2-({[(dimethylamino)carbonyl]-L-phenylalanyl-L-histidyl}amino)-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

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Chemical Property of (2S,3R,4S)-2-({[(dimethylamino)carbonyl]-L-phenylalanyl-L-histidyl}amino)-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

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Technology Process of (2S,3R,4S)-2-({[(dimethylamino)carbonyl]-L-phenylalanyl-L-histidyl}amino)-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

There total 4 articles about (2S,3R,4S)-2-({[(dimethylamino)carbonyl]-L-phenylalanyl-L-histidyl}amino)-1-cyclohexyl-3,4-dihydroxy-6-methylheptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.5%

: 108514-97-2
<(dimethylamino)carbonyl>-L-phenylalanine

: 104882-47-5
(S)-2-Amino-N-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexyl)-3-(1H-imidazol-4-yl)-propionamide; hydrochloride

: 114457-18-0
(2S,3R,4S)-2-({[(dimethylamino)carbonyl]-L-phenylalanyl-L-histidyl}amino)-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; 0 deg C, 2.5 h; 25 deg C, 12 h;
DOI:10.1021/jm00120a006

Reference yield:

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 114457-18-0
(2S,3R,4S)-2-({[(dimethylamino)carbonyl]-L-phenylalanyl-L-histidyl}amino)-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 90 - 100 °C

2: 81 percent / CH₂Cl₂ / 0.17 h / 0 - 5 °C

3: 87 percent / LiOH / dioxane; H₂O / 1 h / 0 - 5 °C

4: 61.5 percent / hydroxybenzotriazole, DCC / dimethylformamide / 0 deg C, 2.5 h; 25 deg C, 12 h

With lithium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00120a006

Reference yield:

: 40203-94-9
methyl (S)-2-isocyanato-3-phenylpropanoate

: 114457-18-0
(2S,3R,4S)-2-({[(dimethylamino)carbonyl]-L-phenylalanyl-L-histidyl}amino)-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / CH₂Cl₂ / 0.17 h / 0 - 5 °C

2: 87 percent / LiOH / dioxane; H₂O / 1 h / 0 - 5 °C

3: 61.5 percent / hydroxybenzotriazole, DCC / dimethylformamide / 0 deg C, 2.5 h; 25 deg C, 12 h

With lithium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00120a006