1-(2-((2-(tert-butyldiphenylsilyloxy)-5-nitrophenyl)ethynyl)phenyl)-3-hexylurea

Base Information

Chemical Name:1-(2-((2-(tert-butyldiphenylsilyloxy)-5-nitrophenyl)ethynyl)phenyl)-3-hexylurea
CAS No.:1353088-23-9
Molecular Formula:C₃₇H₄₁N₃O₄Si
Molecular Weight:619.836
Hs Code.:

Synonyms:1-(2-((2-(tert-butyldiphenylsilyloxy)-5-nitrophenyl)ethynyl)phenyl)-3-hexylurea

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Chemical Property of 1-(2-((2-(tert-butyldiphenylsilyloxy)-5-nitrophenyl)ethynyl)phenyl)-3-hexylurea

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Technology Process of 1-(2-((2-(tert-butyldiphenylsilyloxy)-5-nitrophenyl)ethynyl)phenyl)-3-hexylurea

There total 8 articles about 1-(2-((2-(tert-butyldiphenylsilyloxy)-5-nitrophenyl)ethynyl)phenyl)-3-hexylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1353088-28-4
1-hexyl-3-(2-((2-hydroxy-5-nitrophenyl)ethynyl)phenyl)urea

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1353088-23-9
1-(2-((2-(tert-butyldiphenylsilyloxy)-5-nitrophenyl)ethynyl)phenyl)-3-hexylurea

Guidance literature:: With triethylamine; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.tetlet.2011.11.099

Reference yield:

: 1353088-27-3
2-((2-(3-hexylureido)phenyl)ethynyl)-4-nitrophenyl acetate

: 1353088-23-9
1-(2-((2-(tert-butyldiphenylsilyloxy)-5-nitrophenyl)ethynyl)phenyl)-3-hexylurea

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / methanol / 0.5 h / 20 °C

2: triethylamine / tetrahydrofuran; dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

With hydrazine hydrate; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.tetlet.2011.11.099

Reference yield:

: 2525-62-4,26746-07-6
Hexyl isocyanate

: 1353088-23-9
1-(2-((2-(tert-butyldiphenylsilyloxy)-5-nitrophenyl)ethynyl)phenyl)-3-hexylurea

Guidance literature:: Multi-step reaction with 6 steps

1: dichloromethane / 12 h / 20 °C / Inert atmosphere

2: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 12 h / 55 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

4: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

5: hydrazine hydrate / methanol / 0.5 h / 20 °C

6: triethylamine / tetrahydrofuran; dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; hydrazine hydrate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 2: Sonogashira coupling / 4: Sonogashira coupling;
DOI:10.1016/j.tetlet.2011.11.099