5-<6-(1H-imidazol-1-yl)hexyl>-2-<<4-(1-methylethyl)phenyl>amino>pyridine

Base Information

Chemical Name:5-<6-(1H-imidazol-1-yl)hexyl>-2-<<4-(1-methylethyl)phenyl>amino>pyridine
CAS No.:107962-18-5
Molecular Formula:C₂₃H₃₀N₄
Molecular Weight:362.518
Hs Code.:

Synonyms:5-<6-(1H-imidazol-1-yl)hexyl>-2-<<4-(1-methylethyl)phenyl>amino>pyridine

Suppliers and Price of 5-<6-(1H-imidazol-1-yl)hexyl>-2-<<4-(1-methylethyl)phenyl>amino>pyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-<6-(1H-imidazol-1-yl)hexyl>-2-<<4-(1-methylethyl)phenyl>amino>pyridine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5-<6-(1H-imidazol-1-yl)hexyl>-2-<<4-(1-methylethyl)phenyl>amino>pyridine

There total 8 articles about 5-<6-(1H-imidazol-1-yl)hexyl>-2-<<4-(1-methylethyl)phenyl>amino>pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 107962-13-0
N-<5-<6-(1H-imidazol-1-yl)hexyl>-2-pyridinyl>-N-<4-(1-methylethyl)phenyl>acetamide

: 107962-18-5
5-<6-(1H-imidazol-1-yl)hexyl>-2-<<4-(1-methylethyl)phenyl>amino>pyridine

Guidance literature:: With hydrogenchloride; for 24h; Heating;
DOI:10.1021/jo00388a023

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 107962-18-5
5-<6-(1H-imidazol-1-yl)hexyl>-2-<<4-(1-methylethyl)phenyl>amino>pyridine

Guidance literature:: Multi-step reaction with 7 steps

1: 81 percent / 2 h / 160 - 180 °C

2: 100 percent / acetic acid / 3 h / Heating

3: 92 percent / triethylamine, bis(triphenylphosphine)palladium chloride, cuprous iodide / CH₂Cl₂ / 5 h / Heating

4: 86 percent / H₂ / platinum oxide / ethanol

5: Et₃N / CH₂Cl₂ / 1 h / 0 °C

6: sodium hydride / dimethylformamide / 2 h / 60 °C

7: 87 percent / 6 N HCl / 24 h / Heating

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; sodium hydride; triethylamine; platinum(IV) oxide; In ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jo00388a023

Reference yield:

: 99-88-7
4-Isopropylaniline

: 107962-18-5
5-<6-(1H-imidazol-1-yl)hexyl>-2-<<4-(1-methylethyl)phenyl>amino>pyridine

Guidance literature:: Multi-step reaction with 7 steps

1: 81 percent / 2 h / 160 - 180 °C

2: 100 percent / acetic acid / 3 h / Heating

3: 92 percent / triethylamine, bis(triphenylphosphine)palladium chloride, cuprous iodide / CH₂Cl₂ / 5 h / Heating

4: 86 percent / H₂ / platinum oxide / ethanol

5: Et₃N / CH₂Cl₂ / 1 h / 0 °C

6: sodium hydride / dimethylformamide / 2 h / 60 °C

7: 87 percent / 6 N HCl / 24 h / Heating

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; sodium hydride; triethylamine; platinum(IV) oxide; In ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jo00388a023