ethyl 1-<2-(1,3-dioxolan-2-yl)ethyl>-2-(4-fluorophenyl)-5-(1-methylethyl)-4-phenyl-1H-pyrrole-3-carboxylate

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Chemical Name:ethyl 1-<2-(1,3-dioxolan-2-yl)ethyl>-2-(4-fluorophenyl)-5-(1-methylethyl)-4-phenyl-1H-pyrrole-3-carboxylate
CAS No.:135833-76-0
Molecular Formula:C₂₇H₃₀FNO₄
Molecular Weight:451.538
Hs Code.:

Synonyms:ethyl 1-<2-(1,3-dioxolan-2-yl)ethyl>-2-(4-fluorophenyl)-5-(1-methylethyl)-4-phenyl-1H-pyrrole-3-carboxylate

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Chemical Property of ethyl 1-<2-(1,3-dioxolan-2-yl)ethyl>-2-(4-fluorophenyl)-5-(1-methylethyl)-4-phenyl-1H-pyrrole-3-carboxylate

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Technology Process of ethyl 1-<2-(1,3-dioxolan-2-yl)ethyl>-2-(4-fluorophenyl)-5-(1-methylethyl)-4-phenyl-1H-pyrrole-3-carboxylate

There total 3 articles about ethyl 1-<2-(1,3-dioxolan-2-yl)ethyl>-2-(4-fluorophenyl)-5-(1-methylethyl)-4-phenyl-1H-pyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 104568-93-6
N-<2-(1,3-dioxolan-2-yl)ethyl>-N-(4-fluorobenzoyl)-DL-valine

: 2216-94-6
phenylpropynoic acid ethyl ester

: 1-(2-[1,3]Dioxolan-2-yl-ethyl)-5-(4-fluoro-phenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester

: 135833-76-0
ethyl 1-<2-(1,3-dioxolan-2-yl)ethyl>-2-(4-fluorophenyl)-5-(1-methylethyl)-4-phenyl-1H-pyrrole-3-carboxylate

Guidance literature:: With acetic anhydride; at 110 ℃; for 5h; Yields of byproduct given;
DOI:10.1021/jm00105a056

Reference yield:

: 5754-35-8
2-[1,3]dioxolan-2-yl-ethylamine

: 135833-76-0
ethyl 1-<2-(1,3-dioxolan-2-yl)ethyl>-2-(4-fluorophenyl)-5-(1-methylethyl)-4-phenyl-1H-pyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 55 percent / triethylamine / acetonitrile / 20 h / Heating

2: triethylamine / CH₂Cl₂ / 1.) 0 deg C, 50 min, 2.) RT, 60 min

3: NaOH / methanol; H₂O / 3 h / Heating

4: 30 percent / acetic anhydride / 5 h / 110 °C

With sodium hydroxide; acetic anhydride; triethylamine; In methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm00105a056

Reference yield:

: 104568-94-7
(+/-)-methyl N-(4-fluorobenzoyl)-N-<2-(2-ethyl)-1,3-dioxolanyl>valine

: 135833-76-0
ethyl 1-<2-(1,3-dioxolan-2-yl)ethyl>-2-(4-fluorophenyl)-5-(1-methylethyl)-4-phenyl-1H-pyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: NaOH / methanol; H₂O / 3 h / Heating

2: 30 percent / acetic anhydride / 5 h / 110 °C

With sodium hydroxide; acetic anhydride; In methanol; water;
DOI:10.1021/jm00105a056