methyl 5-amino-2,2-dimethyl-4-(methylamino)-2,3-dihydrobenzofuran-7-carboxylate

Base Information

Chemical Name:methyl 5-amino-2,2-dimethyl-4-(methylamino)-2,3-dihydrobenzofuran-7-carboxylate
CAS No.:1374298-74-4
Molecular Formula:C₁₃H₁₈N₂O₃
Molecular Weight:250.298
Hs Code.:

Synonyms:methyl 5-amino-2,2-dimethyl-4-(methylamino)-2,3-dihydrobenzofuran-7-carboxylate

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Chemical Property of methyl 5-amino-2,2-dimethyl-4-(methylamino)-2,3-dihydrobenzofuran-7-carboxylate

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Technology Process of methyl 5-amino-2,2-dimethyl-4-(methylamino)-2,3-dihydrobenzofuran-7-carboxylate

There total 7 articles about methyl 5-amino-2,2-dimethyl-4-(methylamino)-2,3-dihydrobenzofuran-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1374299-96-3
methyl 2,2-dimethyl-4-(methylamino)-5-nitro-2,3-dihydrobenzofuran-7-carboxylate

: 1374298-74-4
methyl 5-amino-2,2-dimethyl-4-(methylamino)-2,3-dihydrobenzofuran-7-carboxylate

Guidance literature:: methyl 2,2-dimethyl-4-(methylamino)-5-nitro-2,3-dihydrobenzofuran-7-carboxylate; With iron; In methanol; at 0 ℃;

With hydrogenchloride; In methanol; at 20 ℃; for 2h;
DOI:10.1016/j.bmcl.2018.02.048

Reference yield:

: 65-49-6
4-Aminosalicylic acid

: 1374298-74-4
methyl 5-amino-2,2-dimethyl-4-(methylamino)-2,3-dihydrobenzofuran-7-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethanol / Reflux

1.2: 2 h / -5 - 0 °C

2.1: sulfuric acid / Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

4.1: N,N-dimethyl-aniline / 1.5 h / Reflux

4.2: 100 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 0 - 20 °C

6.1: iron / methanol / 0 °C

6.2: 2 h / 20 °C

With sulfuric acid; iron; sodium hydride; potassium carbonate; N,N-dimethyl-aniline; In methanol; ethanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmcl.2018.02.048

Reference yield:

: 82378-91-4
4-acetamido-2-hydroxy-5-nitrobenzoic acid

: 1374298-74-4
methyl 5-amino-2,2-dimethyl-4-(methylamino)-2,3-dihydrobenzofuran-7-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / Reflux

2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

3.1: N,N-dimethyl-aniline / 1.5 h / Reflux

3.2: 100 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 0 - 20 °C

5.1: iron / methanol / 0 °C

5.2: 2 h / 20 °C

With sulfuric acid; iron; sodium hydride; potassium carbonate; N,N-dimethyl-aniline; In methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmcl.2018.02.048