(1'S,2'S,2R)-4-benzyloxy-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-2,N-dimethylbutyramide

Base Information

Chemical Name:(1'S,2'S,2R)-4-benzyloxy-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-2,N-dimethylbutyramide
CAS No.:619328-33-5
Molecular Formula:C₂₂H₂₉NO₃
Molecular Weight:355.477
Hs Code.:

Synonyms:(1'S,2'S,2R)-4-benzyloxy-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-2,N-dimethylbutyramide

Suppliers and Price of (1'S,2'S,2R)-4-benzyloxy-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-2,N-dimethylbutyramide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1'S,2'S,2R)-4-benzyloxy-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-2,N-dimethylbutyramide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1'S,2'S,2R)-4-benzyloxy-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-2,N-dimethylbutyramide

There total 1 articles about (1'S,2'S,2R)-4-benzyloxy-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-2,N-dimethylbutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 54555-84-9
benzyl iodoethyl ether

: 159213-03-3
N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylpropionamide

: 619328-33-5
(1'S,2'S,2R)-4-benzyloxy-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-2,N-dimethylbutyramide

Guidance literature:: N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylpropionamide; With lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1.33333h;

benzyl iodoethyl ether; In tetrahydrofuran; hexane; at 20 ℃; for 15h;
DOI:10.1039/b404205k

Reference yield: 90.0%

: 619328-33-5
(1'S,2'S,2R)-4-benzyloxy-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-2,N-dimethylbutyramide

: 96154-47-1
(R)-2-methyl-1,4-butanediol 4-benzyl ether

Guidance literature:: With borane-ammonia complex; lithium diisopropyl amide; In tetrahydrofuran; at 20 ℃; for 2.5h;
DOI:10.1039/b404205k

Reference yield:

: 619328-33-5
(1'S,2'S,2R)-4-benzyloxy-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-2,N-dimethylbutyramide

: 619328-35-7
(4S,2'S,3'S,5'S)-3-(7'-oxo-2',3',5'-trimethylheptanoyl)-4-phenyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / LDA; BH₃*NH₃ / tetrahydrofuran / 2.5 h / 20 °C

2: 74 percent / NBS; PPh₃ / CH₂Cl₂ / 0.17 h / 20 °C

3: 100 percent / H₂ / Pd(OH)2 / ethyl acetate / 2 h

4: 85 percent / oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / 0.75 h / -78 - 0 °C

With N-Bromosuccinimide; borane-ammonia complex; oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine; triphenylphosphine; lithium diisopropyl amide; palladium dihydroxide; In tetrahydrofuran; dichloromethane; ethyl acetate; 5: Swern oxidation;
DOI:10.1039/b404205k