N₅-(4-fluorobenzyl)-N₂,3-dihydroxy-4-(hydroxymethyl)pyridine-2,5-dicarboxamide

Base Information

Chemical Name:N₅-(4-fluorobenzyl)-N₂,3-dihydroxy-4-(hydroxymethyl)pyridine-2,5-dicarboxamide
CAS No.:1198620-30-2
Molecular Formula:C₁₅H₁₄FN₃O₅
Molecular Weight:335.292
Hs Code.:

N<sub>5</sub>-(4-fluorobenzyl)-N<sub>2</sub>,3-dihydroxy-4-(hydroxymethyl)pyridine-2,5-dicarboxamide

Synonyms:N₅-(4-fluorobenzyl)-N₂,3-dihydroxy-4-(hydroxymethyl)pyridine-2,5-dicarboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N₅-(4-fluorobenzyl)-N₂,3-dihydroxy-4-(hydroxymethyl)pyridine-2,5-dicarboxamide

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Technology Process of N₅-(4-fluorobenzyl)-N₂,3-dihydroxy-4-(hydroxymethyl)pyridine-2,5-dicarboxamide

There total 5 articles about N₅-(4-fluorobenzyl)-N₂,3-dihydroxy-4-(hydroxymethyl)pyridine-2,5-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1198620-29-9
N₂,3-bis(benzyloxy)-N₅-(4-fluorobenzyl)-4-(hydroxymethyl)pyridine-2,5-dicarboxamide

: 1198620-30-2
N₅-(4-fluorobenzyl)-N₂,3-dihydroxy-4-(hydroxymethyl)pyridine-2,5-dicarboxamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; for 1h;

Reference yield:

: 1198621-04-3
N,3-bis(benzyloxy)-4,5-bis(hydroxymethyl)picolinamide

: 1198620-30-2
N₅-(4-fluorobenzyl)-N₂,3-dihydroxy-4-(hydroxymethyl)pyridine-2,5-dicarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: manganese(IV) oxide / dichloromethane / 20 °C

2: 0.5 h / 70 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 1 h

With manganese(IV) oxide; hydrogen; palladium 10% on activated carbon; In methanol; dichloromethane;

Reference yield:

: 62489-21-8
9-benzyloxy-3,3-dimethyl-1,5-dihydro-[1,3]dioxepino[5,6-c]pyridine-8-carboxylic acid methyl ester

: 1198620-30-2
N₅-(4-fluorobenzyl)-N₂,3-dihydroxy-4-(hydroxymethyl)pyridine-2,5-dicarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C

1.2: 0.5 h / -78 °C

2.1: formic acid / tetrahydrofuran; water / 2 h / 70 °C

3.1: manganese(IV) oxide / dichloromethane / 20 °C

4.1: 0.5 h / 70 °C

5.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h

With manganese(IV) oxide; formic acid; hydrogen; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water;