benzyl [(2S,4R)-4-(4-benzyloxybenzyl)-2-phenyl-5-oxodioxolan-4-yl]acetate

Base Information

• Chemical Name: benzyl [(2S,4R)-4-(4-benzyloxybenzyl)-2-phenyl-5-oxodioxolan-4-yl]acetate
• CAS No.: 1141933-41-6
• Molecular Formula: C₃₂H₂₈O₆
• Molecular Weight: 508.571
• Mol file: 1141933-41-6.mol

Synonyms:benzyl [(2S,4R)-4-(4-benzyloxybenzyl)-2-phenyl-5-oxodioxolan-4-yl]acetate

Chemical Property of benzyl [(2S,4R)-4-(4-benzyloxybenzyl)-2-phenyl-5-oxodioxolan-4-yl]acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of benzyl [(2S,4R)-4-(4-benzyloxybenzyl)-2-phenyl-5-oxodioxolan-4-yl]acetate

There total 1 articles about benzyl [(2S,4R)-4-(4-benzyloxybenzyl)-2-phenyl-5-oxodioxolan-4-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

(2S,4S)-4-(4-benzyloxybenzyl)-2-phenyl-5-oxodioxolane (1141933-39-2) + Benzyl bromoacetate (5437-45-6) → benzyl [(2S,4R)-4-(4-benzyloxybenzyl)-2-phenyl-5-oxodioxolan-4-yl]acetate (1141933-41-6)

Guidance literature:

(2S,4S)-4-(4-benzyloxybenzyl)-2-phenyl-5-oxodioxolane; With lithium diisopropyl amide; In tetrahydrofuran; at -80 ℃; Inert atmosphere;

Benzyl bromoacetate; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -60 ℃; diastereoselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2008.11.097

Reference yield: 89.0%

benzyl [(2S,4R)-4-(4-benzyloxybenzyl)-2-phenyl-5-oxodioxolan-4-yl]acetate (1141933-41-6) → (2R)-2-(p-hydroxybenzyl)malic acid (60449-48-1)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In methanol; at 20 ℃;

DOI:10.1016/j.tet.2008.11.097

upstream raw materials:

(2S,4S)-4-(4-benzyloxybenzyl)-2-phenyl-5-oxodioxolane

Benzyl bromoacetate

Downstream raw materials:

(2R)-2-(p-hydroxybenzyl)malic acid