1-[1-[3-(2-amino-ethyl)-1H-indol-2-yl]-1-(1-benzenesulfonyl-1H-indol-3-yl)-1,3,4,9-tetrahydro-β-carbolin-2-yl]-2,2,2-trifluoro-ethanone

Base Information

Chemical Name:1-[1-[3-(2-amino-ethyl)-1H-indol-2-yl]-1-(1-benzenesulfonyl-1H-indol-3-yl)-1,3,4,9-tetrahydro-β-carbolin-2-yl]-2,2,2-trifluoro-ethanone
CAS No.:615574-49-7
Molecular Formula:C₃₇H₃₀F₃N₅O₃S
Molecular Weight:681.738
Hs Code.:

1-[1-[3-(2-amino-ethyl)-1<i>H</i>-indol-2-yl]-1-(1-benzenesulfonyl-1<i>H</i>-indol-3-yl)-1,3,4,9-tetrahydro-β-carbolin-2-yl]-2,2,2-trifluoro-ethanone

Synonyms:1-[1-[3-(2-amino-ethyl)-1H-indol-2-yl]-1-(1-benzenesulfonyl-1H-indol-3-yl)-1,3,4,9-tetrahydro-β-carbolin-2-yl]-2,2,2-trifluoro-ethanone

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Chemical Property of 1-[1-[3-(2-amino-ethyl)-1H-indol-2-yl]-1-(1-benzenesulfonyl-1H-indol-3-yl)-1,3,4,9-tetrahydro-β-carbolin-2-yl]-2,2,2-trifluoro-ethanone

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Technology Process of 1-[1-[3-(2-amino-ethyl)-1H-indol-2-yl]-1-(1-benzenesulfonyl-1H-indol-3-yl)-1,3,4,9-tetrahydro-β-carbolin-2-yl]-2,2,2-trifluoro-ethanone

There total 6 articles about 1-[1-[3-(2-amino-ethyl)-1H-indol-2-yl]-1-(1-benzenesulfonyl-1H-indol-3-yl)-1,3,4,9-tetrahydro-β-carbolin-2-yl]-2,2,2-trifluoro-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 615574-47-5
(2-{2-[1-(1-benzenesulfonyl-1H-indol-3-yl)-2-trifluoroacetyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl]-1H-indol-3-yl}-ethyl)-carbamic acid benzyl ester

: 615574-49-7
1-[1-[3-(2-amino-ethyl)-1H-indol-2-yl]-1-(1-benzenesulfonyl-1H-indol-3-yl)-1,3,4,9-tetrahydro-β-carbolin-2-yl]-2,2,2-trifluoro-ethanone

: 1-(1-benzenesulfonyl-1H-indol-3-yl)-1-{3-[2-(2,2,2-trifluoro-acetylamino)-ethyl]-1H-indol-2-yl}-1,3,4,9-tetrahydro-β-carboline-2-carboxylic acid benzyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 20h;
DOI:10.1055/s-2003-40836

Reference yield:

: 61-54-1
tryptamine

: 615574-49-7
1-[1-[3-(2-amino-ethyl)-1H-indol-2-yl]-1-(1-benzenesulfonyl-1H-indol-3-yl)-1,3,4,9-tetrahydro-β-carbolin-2-yl]-2,2,2-trifluoro-ethanone

Guidance literature:: Multi-step reaction with 6 steps

1: aq. K₂CO₃ / ethyl acetate / 20 h / 20 °C

2: POCl₃ / 3 h / 80 °C

3: 42 percent / aq. Na₂CO₃ / CH₂Cl₂ / 20 h / 20 °C

4: 67 percent / ZnCl₂ / xylene / 1 h / 130 °C / microwave irradiation

5: 67 percent / CH₂Cl₂ / 15 h / 45 °C

6: 50 percent / H₂ / Pd/C / methanol / 20 h / 20 °C

With hydrogen; sodium carbonate; potassium carbonate; zinc(II) chloride; trichlorophosphate; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; xylene; 2: Bischler-Napieralski cyclization / 3: Schotten-Baumann reaction;
DOI:10.1055/s-2003-40836

Reference yield:

: 615574-45-3
1-benzenesulfonyl-1H-indole-3-carboxylic acid [2-(1H-indol-3-yl)-ethyl]-amide

: 615574-49-7
1-[1-[3-(2-amino-ethyl)-1H-indol-2-yl]-1-(1-benzenesulfonyl-1H-indol-3-yl)-1,3,4,9-tetrahydro-β-carbolin-2-yl]-2,2,2-trifluoro-ethanone

Guidance literature:: Multi-step reaction with 5 steps

1: POCl₃ / 3 h / 80 °C

2: 42 percent / aq. Na₂CO₃ / CH₂Cl₂ / 20 h / 20 °C

3: 67 percent / ZnCl₂ / xylene / 1 h / 130 °C / microwave irradiation

4: 67 percent / CH₂Cl₂ / 15 h / 45 °C

5: 50 percent / H₂ / Pd/C / methanol / 20 h / 20 °C

With hydrogen; sodium carbonate; zinc(II) chloride; trichlorophosphate; palladium on activated charcoal; In methanol; dichloromethane; xylene; 1: Bischler-Napieralski cyclization / 2: Schotten-Baumann reaction;
DOI:10.1055/s-2003-40836