ethyl 4-(methylthio)-2-[2-(trifluoromethyl)phenyl]thiophene-3-carboxylate

Base Information

Chemical Name:ethyl 4-(methylthio)-2-[2-(trifluoromethyl)phenyl]thiophene-3-carboxylate
CAS No.:1097189-85-9
Molecular Formula:C₁₅H₁₃F₃O₂S₂
Molecular Weight:346.394
Hs Code.:

Synonyms:ethyl 4-(methylthio)-2-[2-(trifluoromethyl)phenyl]thiophene-3-carboxylate

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Chemical Property of ethyl 4-(methylthio)-2-[2-(trifluoromethyl)phenyl]thiophene-3-carboxylate

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Technology Process of ethyl 4-(methylthio)-2-[2-(trifluoromethyl)phenyl]thiophene-3-carboxylate

There total 1 articles about ethyl 4-(methylthio)-2-[2-(trifluoromethyl)phenyl]thiophene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1097189-80-4
ethyl 4-(methylthio)thiophene-3-carboxylate

: 444-29-1
2-iodo(trifluoromethyl)benzene

: 1097189-85-9
ethyl 4-(methylthio)-2-[2-(trifluoromethyl)phenyl]thiophene-3-carboxylate

Guidance literature:: ethyl 4-(methylthio)thiophene-3-carboxylate; With 2,2,6,6-tetramethylpiperidinylmagnesium chloride; In tetrahydrofuran; at -30 ℃; for 0.5h; Inert atmosphere;

With zinc(II) chloride; In tetrahydrofuran; for 0.25h; Inert atmosphere;

2-iodo(trifluoromethyl)benzene; With trifuran-2-yl-phosphane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; at -30 - 50 ℃; Inert atmosphere;
DOI:10.1021/ol802513q

Reference yield: 86.0%

: 1097189-85-9
ethyl 4-(methylthio)-2-[2-(trifluoromethyl)phenyl]thiophene-3-carboxylate

: 1521-51-3,113667-32-6
rac-3-bromocyclohexene

: 1097189-93-9
ethyl 5-cyclohex-2-en-1-yl-4-(methylthio)-2-[2-(trifluoromethyl)phenyl]thiophene-3-carboxylate

Guidance literature:: ethyl 4-(methylthio)-2-[2-(trifluoromethyl)phenyl]thiophene-3-carboxylate; With 2,2,6,6-tetramethylpiperidinylmagnesium chloride; In tetrahydrofuran; at -30 ℃; for 1h; Inert atmosphere;

With copper(I) cyanide*2 lithium chloride; In tetrahydrofuran; for 0.25h; Inert atmosphere;

rac-3-bromocyclohexene; In tetrahydrofuran; at -30 - 25 ℃;
DOI:10.1021/ol802513q

Reference yield: 85.0%

: 1097189-85-9
ethyl 4-(methylthio)-2-[2-(trifluoromethyl)phenyl]thiophene-3-carboxylate

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 1097189-94-0
ethyl 5-formyl-4-(methylthio)-2-[2-(trifluoromethyl)phenyl]thiophene-3-carboxylate

Guidance literature:: ethyl 4-(methylthio)-2-[2-(trifluoromethyl)phenyl]thiophene-3-carboxylate; With 2,2,6,6-tetramethylpiperidinylmagnesium chloride; In tetrahydrofuran; at -30 ℃; for 1h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; at -30 - 25 ℃; Inert atmosphere;
DOI:10.1021/ol802513q