N-[benzotriazol-1-yl-(4-bromo-phenyl)-methyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-(3-methoxy-phenyl)-propionamide

Base Information

• Chemical Name: N-[benzotriazol-1-yl-(4-bromo-phenyl)-methyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-(3-methoxy-phenyl)-propionamide
• CAS No.: 872690-16-9
• Molecular Formula: C₃₁H₂₄BrN₅O₄
• Molecular Weight: 610.467

Synonyms:N-[benzotriazol-1-yl-(4-bromo-phenyl)-methyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-(3-methoxy-phenyl)-propionamide

Chemical Property of N-[benzotriazol-1-yl-(4-bromo-phenyl)-methyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-(3-methoxy-phenyl)-propionamide

Chemical Property:

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Technology Process of N-[benzotriazol-1-yl-(4-bromo-phenyl)-methyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-(3-methoxy-phenyl)-propionamide

There total 3 articles about N-[benzotriazol-1-yl-(4-bromo-phenyl)-methyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-(3-methoxy-phenyl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-(3-methoxy-phenyl)-propionyl chloride + 1,2,3-Benzotriazole (95-14-7,27556-51-0) + α-Phthalimido-β-(3-methoxyphenyl)-propionamid (56876-11-0) → N-[benzotriazol-1-yl-(4-bromo-phenyl)-methyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-(3-methoxy-phenyl)-propionamide (872690-16-9)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; Heating;

DOI:10.1055/s-2005-918946

Reference yield:

α-Phthalimido-β-(3-methoxyphenyl)-propionsaeure (56876-08-5) → N-[benzotriazol-1-yl-(4-bromo-phenyl)-methyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-(3-methoxy-phenyl)-propionamide (872690-16-9)

Guidance literature:

Multi-step reaction with 3 steps

1: α,α-dichloromethyl methyl ether

2: aq. NH₃

3: 100 percent / p-TsOH / benzene / Heating

With ammonium hydroxide; Dichloromethyl methyl ether; toluene-4-sulfonic acid; In benzene;

DOI:10.1055/s-2005-918946

Reference yield:

2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-(3-methoxy-phenyl)-propionyl chloride → N-[benzotriazol-1-yl-(4-bromo-phenyl)-methyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-(3-methoxy-phenyl)-propionamide (872690-16-9)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NH₃

2: 100 percent / p-TsOH / benzene / Heating

With ammonium hydroxide; toluene-4-sulfonic acid; In benzene;

DOI:10.1055/s-2005-918946

upstream raw materials:

1,2,3-Benzotriazole

α-Phthalimido-β-(3-methoxyphenyl)-propionamid

α-Phthalimido-β-(3-methoxyphenyl)-propionsaeure

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