(S)-dimethyl 2-oxo-3-palmitamido-4-(4-(pyridin-2-ylmethoxy)phenyl)butylphosphonate

Base Information

Chemical Name:(S)-dimethyl 2-oxo-3-palmitamido-4-(4-(pyridin-2-ylmethoxy)phenyl)butylphosphonate
CAS No.:935548-36-0
Molecular Formula:C₃₄H₅₃N₂O₆P
Molecular Weight:616.778
Hs Code.:

Synonyms:(S)-dimethyl 2-oxo-3-palmitamido-4-(4-(pyridin-2-ylmethoxy)phenyl)butylphosphonate

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Chemical Property of (S)-dimethyl 2-oxo-3-palmitamido-4-(4-(pyridin-2-ylmethoxy)phenyl)butylphosphonate

Chemical Property:

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Technology Process of (S)-dimethyl 2-oxo-3-palmitamido-4-(4-(pyridin-2-ylmethoxy)phenyl)butylphosphonate

There total 5 articles about (S)-dimethyl 2-oxo-3-palmitamido-4-(4-(pyridin-2-ylmethoxy)phenyl)butylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 935548-18-8
(S)-methyl 2-palmitamido-3-(4-(pyridin-2-ylmethoxy)phenyl)propanoate

: 756-79-6
dimethyl methane phosphonate

: 935548-36-0
(S)-dimethyl 2-oxo-3-palmitamido-4-(4-(pyridin-2-ylmethoxy)phenyl)butylphosphonate

Guidance literature:: dimethyl methane phosphonate; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.25h; Inert atmosphere;

(S)-methyl 2-palmitamido-3-(4-(pyridin-2-ylmethoxy)phenyl)propanoate; In tetrahydrofuran; at -78 ℃; for 0.333333h; Inert atmosphere;
DOI:10.1016/j.bmcl.2010.09.030

Reference yield:

: 3417-91-2
L-tyrosine methyl ester HCl

: 935548-36-0
(S)-dimethyl 2-oxo-3-palmitamido-4-(4-(pyridin-2-ylmethoxy)phenyl)butylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: Et₃N / CH₂Cl₂ / 3 h / 0 °C

2.1: K₂CO₃; 18-crown-6 / acetone / Heating

3.1: n-BuLi

3.2: 3 h / -78 °C

With n-butyllithium; 18-crown-6 ether; potassium carbonate; triethylamine; In dichloromethane; acetone;
DOI:10.1016/j.bmcl.2006.12.114

Reference yield:

: 215035-91-9
pyridin-2-ylmethyl methanesulphonate

: 935548-36-0
(S)-dimethyl 2-oxo-3-palmitamido-4-(4-(pyridin-2-ylmethoxy)phenyl)butylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: K₂CO₃; 18-crown-6 / acetone / Heating

2.1: n-BuLi

2.2: 3 h / -78 °C

With n-butyllithium; 18-crown-6 ether; potassium carbonate; In acetone;
DOI:10.1016/j.bmcl.2006.12.114