Urea,N-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-

Base Information

• Chemical Name: Urea,N-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-
• CAS No.: 179343-17-0
• Molecular Formula: C18H18 Cl2 N6 O
• Molecular Weight: 405.287
• Mol file: 179343-17-0.mol

Synonyms:PD 089828

Chemical Property of Urea,N-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Urea,N-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-

There total 4 articles about Urea,N-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-diamino-5-pyrimidinecarboxaldehyde (20781-06-0) → PD 089828 (179343-17-0)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / 2-ethoxy-ethanol / Heating

2: 1) NaH / 1) DMF, room temperature, 1 h

With sodium hydride; In 2-ethoxy-ethanol;

DOI:10.1016/S0960-894X(97)00445-9

Reference yield:

2,7-diamino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]-pyrimidine (26752-70-5) + Tert-butyl isocyanate (1609-86-5) → PD 089828 (179343-17-0) + 1-tert-butyl-3-[7-(3-tert-butylureido)-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidin-2-yl]urea

Guidance literature:

With sodium hydride; Yield given. Multistep reaction. Yields of byproduct given; 1.) DMF, RT, 1 h, 2.) DMF, RT, 16 h;

DOI:10.1021/jm970367n

Reference yield:

2,7-diamino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]-pyrimidine (26752-70-5) + Tert-butyl isocyanate (1609-86-5) → PD 089828 (179343-17-0)

Guidance literature:

With sodium hydride; Multistep reaction; 1) DMF, room temperature, 1 h;

DOI:10.1016/S0960-894X(97)00445-9

upstream raw materials:

2,7-diamino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]-pyrimidine

Tert-butyl isocyanate

2,4-diamino-5-pyrimidinecarboxaldehyde